Midbrain atrophy patients with presymptomatic progressive supranuclear palsy-Richardson's syndrome
DC Field | Value | Language |
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dc.contributor.author | Ahn, Jong Hyeon | - |
dc.contributor.author | Kim, Minkyeong | - |
dc.contributor.author | Kim, Ji Sun | - |
dc.contributor.author | Youn, Jinyoung | - |
dc.contributor.author | Jang, Wooyoung | - |
dc.contributor.author | Oh, Eungseok | - |
dc.contributor.author | Lee, Phil Hyu | - |
dc.contributor.author | Koh, Seong-Beom | - |
dc.contributor.author | Ahn, Tae-Beom | - |
dc.contributor.author | Cho, Jin Whan | - |
dc.date.accessioned | 2021-09-01T07:44:46Z | - |
dc.date.available | 2021-09-01T07:44:46Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/63047 | - |
dc.description.abstract | Introduction In the present study, midbrain atrophy and the pons-to-midbrain area ratio (P/M ratio) were investigated as diagnostic markers for presymptomatic progressive supranuclear palsy-Richardson's syndrome (Pre-PSP-RS). Methods: The present study included 27 patients with probable PSP-RS who underwent brain MRI at least twice before and after the development of clinical symptoms, age- and sex-matched participants with Parkinson's disease (PD, n = 27), and healthy controls (n = 27). The midbrain area, pons area, and P/M ratio of the Pre-PSP-RS, PD, and control subjects were measured using midsagittal images from brain MRI, and the parameters were compared among the groups. Results: The midbrain area decreased and the P/M ratio increased significantly in the Pre-PSP-RS patients compared with both the PD and control subjects (midbrain, Pre-PSP-RS vs. PD = 1.01 cm(2) vs. 1.29 cm(2), p < 0.001, Pre-PSP-RS vs. controls = 1.01 cm(2) vs. 1.29 cm(2), p < 0.001; P/M ratio, Pre-PSP-RS vs. PD = 5.27 vs. 4.03, p < 0.001, Pre-PSP-RS vs. controls = 5.27 cm(2) vs. 4.06 cm(2), p < 0.001). The P/M ratio had high sensitivity (vs. PD, 96.3%, vs. control, 88.9%) and specificity (vs. PD, 81.5%, vs. control, 96.3%) in differentiating Pre-PSP-RS patients from PD and control subjects. Conclusion: Midbrain atrophy precedes the clinical symptoms of PSP-RS and could be a useful diagnostic imaging biomarker for Pre-PSP-RS. Furthermore, this information could play an important role in the development of future treatment strategies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | RESONANCE PARKINSONISM INDEX | - |
dc.subject | MULTIPLE SYSTEM ATROPHY | - |
dc.subject | CLINICAL-DIAGNOSIS | - |
dc.subject | BRAIN ATROPHY | - |
dc.subject | ELDERLY BRAIN | - |
dc.subject | MRI | - |
dc.subject | ACCURACY | - |
dc.subject | DISEASE | - |
dc.subject | PSP | - |
dc.subject | PREVALENCE | - |
dc.title | Midbrain atrophy patients with presymptomatic progressive supranuclear palsy-Richardson's syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Seong-Beom | - |
dc.identifier.doi | 10.1016/j.parkreldis.2019.07.009 | - |
dc.identifier.scopusid | 2-s2.0-85068734654 | - |
dc.identifier.wosid | 000491684100014 | - |
dc.identifier.bibliographicCitation | PARKINSONISM & RELATED DISORDERS, v.66, pp.80 - 86 | - |
dc.relation.isPartOf | PARKINSONISM & RELATED DISORDERS | - |
dc.citation.title | PARKINSONISM & RELATED DISORDERS | - |
dc.citation.volume | 66 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 86 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | RESONANCE PARKINSONISM INDEX | - |
dc.subject.keywordPlus | MULTIPLE SYSTEM ATROPHY | - |
dc.subject.keywordPlus | CLINICAL-DIAGNOSIS | - |
dc.subject.keywordPlus | BRAIN ATROPHY | - |
dc.subject.keywordPlus | ELDERLY BRAIN | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PSP | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordAuthor | Progressive supranuclear palsy | - |
dc.subject.keywordAuthor | Midbrain atrophy | - |
dc.subject.keywordAuthor | Pons-to-midbrain ratio | - |
dc.subject.keywordAuthor | Presymptomatic PSP | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Richardson&apos | - |
dc.subject.keywordAuthor | s syndrome | - |
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