Baseline D-Dimer Levels as a Risk Assessment Biomarker for Recurrent Stroke in Patients with Combined Atrial Fibrillation and Atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | Choi, Kang-Ho | - |
dc.contributor.author | Seo, Woo-Keun | - |
dc.contributor.author | Park, Man-Seok | - |
dc.contributor.author | Kim, Joon-Tae | - |
dc.contributor.author | Chung, Jong-Won | - |
dc.contributor.author | Bang, Oh Young | - |
dc.contributor.author | Kim, Geong-Moon | - |
dc.contributor.author | Song, Tae-Jin | - |
dc.contributor.author | Kim, Bum Joon | - |
dc.contributor.author | Heo, Sung Hyuk | - |
dc.contributor.author | Jung, Jin-Man | - |
dc.contributor.author | Oh, Kyungmi | - |
dc.contributor.author | Kim, Chi Kyung | - |
dc.contributor.author | Yu, Sungwook | - |
dc.contributor.author | Park, Kwang Yeol | - |
dc.contributor.author | Kim, Jeong-Min | - |
dc.contributor.author | Park, Jong-Ho | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Hwang, Yang-Ha | - |
dc.contributor.author | Kim, Yong-Jae | - |
dc.date.accessioned | 2021-09-01T07:48:09Z | - |
dc.date.available | 2021-09-01T07:48:09Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/63079 | - |
dc.description.abstract | Background: We investigated the effect of D-dimer levels and efficacy of different antithrombotic therapies according to the baseline D-dimer levels on recurrent stroke in patients with atrial fibrillation (AF)-related stroke and atherosclerosis. Methods: We enrolled 1441 patients with AF-related stroke and atherosclerosis in this nationwide multicenter study. The primary outcome measure was the occurrence of recurrent ischemic stroke over a 3-year period. Results: High D-dimer levels (>= 2 mu g/mL) were significantly associated with higher risk of recurrent ischemic stroke (adjusted hazard ratio (HR), 1.80; 95% confidence interval (CI), 1.13-2.84; p = 0.012). The risk of recurrent stroke was similar between the anticoagulant and the antiplatelet groups in all subjects (adjusted HR, 0.78; 95% CI, 0.46-1.32; p = 0.369). However, in patients with high D-dimer levels (>= 2 mu g/mL), risk of recurrent stroke was significantly lower in the anticoagulant group than in the antiplatelet group (adjusted HR, 0.40; 95% CI, 0.18-0.87; p = 0.022). Conclusion: Our findings suggested that baseline D-dimer levels could be used as a risk assessment biomarker of recurrent stroke in patients with AF-related stroke and atherosclerosis. High D-dimer levels would facilitate the identification of patients who are more likely to benefit from anticoagulants to ensure secondary prevention of stroke. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | FREE FATTY-ACID | - |
dc.subject | TRANSESOPHAGEAL ECHOCARDIOGRAPHY | - |
dc.subject | APPENDAGE THROMBI | - |
dc.subject | ANTICOAGULATION | - |
dc.subject | WARFARIN | - |
dc.subject | ASSOCIATION | - |
dc.subject | PREVALENCE | - |
dc.subject | PREVENTION | - |
dc.subject | OUTCOMES | - |
dc.title | Baseline D-Dimer Levels as a Risk Assessment Biomarker for Recurrent Stroke in Patients with Combined Atrial Fibrillation and Atherosclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Jin-Man | - |
dc.contributor.affiliatedAuthor | Oh, Kyungmi | - |
dc.contributor.affiliatedAuthor | Kim, Chi Kyung | - |
dc.contributor.affiliatedAuthor | Yu, Sungwook | - |
dc.identifier.doi | 10.3390/jcm8091457 | - |
dc.identifier.wosid | 000489184200191 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.9 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | FREE FATTY-ACID | - |
dc.subject.keywordPlus | TRANSESOPHAGEAL ECHOCARDIOGRAPHY | - |
dc.subject.keywordPlus | APPENDAGE THROMBI | - |
dc.subject.keywordPlus | ANTICOAGULATION | - |
dc.subject.keywordPlus | WARFARIN | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | d-dimer | - |
dc.subject.keywordAuthor | outcome | - |
dc.subject.keywordAuthor | ischemic stroke | - |
dc.subject.keywordAuthor | antithrombotics | - |
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