A Modular and Practical Synthesis of Zwitterionic Hydrogels through Sequential Amine-Epoxy "Click" Chemistry and N-Alkylation Reaction
- Authors
- Oh, Junki; Jung, Kevin Injoe; Jung, Hyun Wook; Khan, Anzar
- Issue Date
- 9월-2019
- Publisher
- MDPI
- Keywords
- amine-epoxy reaction; " click" chemistry; poly(beta-hydroxyl amine)s; hydrogel synthesis; sequential reactions; " click" hydrogels; hydrogel patterning
- Citation
- POLYMERS, v.11, no.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- POLYMERS
- Volume
- 11
- Number
- 9
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/63394
- DOI
- 10.3390/polym11091491
- ISSN
- 2073-4360
- Abstract
- In this work, the amine-epoxy click reaction is shown to be a valuable general tool in the synthesis of reactive hydrogels. The practicality of this reaction arises due to its catalyst-free nature, its operation in water, and commercial availability of a large variety of amine and epoxide molecules that can serve as hydrophilic network precursors. Therefore, hydrogels can be prepared in a modular fashion through a simple mixing of the precursors in water and used as produced (without requiring any post-synthesis purification step). The gelation behavior and final hydrogel properties depend upon the molecular weight of the precursors and can be changed as per the requirement. A post-synthesis modification through alkylation at the nitrogen atom of the newly formed beta-hydroxyl amine linkages allows for functionalizing the hydrogels. For example, ring-opening reaction of cyclic sulfonic ester gives rise to surfaces with a zwitterionic character. Finally, the established gelation chemistry can be combined with soft lithography techniques such as micromolding in capillaries (MIMIC) to obtain hydrogel microstructures.
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Collections - College of Engineering > Department of Chemical and Biological Engineering > 1. Journal Articles
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