Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease in Patients With Type 2 Diabetes
- Authors
- Lee, Hoyoon; Na, Wonwhi; Lee, Sang Bae; Ahn, Chul Woo; Moon, Jun Sung; Won, Kyu Chang; Shin, Sehyun
- Issue Date
- 20-8월-2019
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- diabetic nephropathy; chronic kidney disease; deformability; critical shear stress; diagnosis
- Citation
- FRONTIERS IN PHYSIOLOGY, v.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN PHYSIOLOGY
- Volume
- 10
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/63495
- DOI
- 10.3389/fphys.2019.01062
- ISSN
- 1664-042X
- Abstract
- Many studies have demonstrated that an alteration in hemorheological properties is closely correlated with diabetic microcirculatory diseases. However, most of these studies have been limited to animal studies or used a small number of clinical samples, due to a lack of effective point-of-care (POC) devices to measure such properties within clinical environments. Owing to recent developments in microfluidic technology, several hemorheological POC devices have been designed that allow for the possibility of conducting extensive clinical studies using hemorheological measurements. Here, we reviewed recent clinical studies of diabetic kidney disease (DKD) associated with hemorheological parameters. We found that RBC deformability alone did not show a significant difference according to the degree of DKD, whereas critical shear stress (CSS) was found to be closely related to the ratio of albumin to creatinine and glomerular filtration rate. We also reviewed studies that alteration of hemorheological properties are associated with the development of DKD, which showed that CSS could be considered as a potential index to diagnose other diabetic complications as well as DKD.
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Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
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