Oncostatin M, a muscle-secreted myokine, recovers high-glucose-induced impairment of Akt phosphorylation by Fos induction in hippocampal neuron cells
DC Field | Value | Language |
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dc.contributor.author | Hyung, William Won Seok | - |
dc.contributor.author | Lee, Sung Gon | - |
dc.contributor.author | Kim, Keun Tae | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.date.accessioned | 2021-09-01T09:38:56Z | - |
dc.date.available | 2021-09-01T09:38:56Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-08-07 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/63551 | - |
dc.description.abstract | Oncostatin M is a muscle-secreted myokine that has various effects on neuronal function, however, the underlying molecular mechanism has been poorly defined. In this study, we showed that Oncostatin M increased the phosphorylation of Akt and ERK, proteins crucial for neuron cell survival and proliferation. Furthermore, Oncostatin M increased the expression of c-Fos, a protein with significant involvement in neuronal cell proliferation and survival, through both Akt and ERK. Oncostatin M also increased intracellular calcium concentrations that act upstream of Akt and ERK. Treatment with Oncostatin M led to the recovery of high-glucose-induced impairment of Akt phosphorylation. Thus, Oncostatin M can protect neuronal cell damage related to high-glucose conditions, showing potential as a therapeutic agent. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | EXERCISE | - |
dc.subject | INTERLEUKIN-6 | - |
dc.subject | PATHOGENESIS | - |
dc.title | Oncostatin M, a muscle-secreted myokine, recovers high-glucose-induced impairment of Akt phosphorylation by Fos induction in hippocampal neuron cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Soo | - |
dc.identifier.doi | 10.1097/WNR.0000000000001271 | - |
dc.identifier.scopusid | 2-s2.0-85069264476 | - |
dc.identifier.wosid | 000480684000003 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, v.30, no.11, pp.765 - 770 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.citation.title | NEUROREPORT | - |
dc.citation.volume | 30 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 765 | - |
dc.citation.endPage | 770 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | c-Fos | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | high-glucose | - |
dc.subject.keywordAuthor | Oncostatin M | - |
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