Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer's dementia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Myungwon | - |
dc.contributor.author | Youn, HyunChul | - |
dc.contributor.author | Kim, Daegyeom | - |
dc.contributor.author | Lee, Suji | - |
dc.contributor.author | Suh, Sangil | - |
dc.contributor.author | Seong, Joon-Kyung | - |
dc.contributor.author | Jeong, Hyun-Ghang | - |
dc.contributor.author | Han, Cheol E. | - |
dc.date.accessioned | 2021-09-01T10:02:16Z | - |
dc.date.available | 2021-09-01T10:02:16Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-08-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/63582 | - |
dc.description.abstract | Several metrics of analysis of magnetic resonance imaging (MRI) have been used to assess Alzheimer's disease (AD)-related neurodegeneration. We compared four structural brain MRI analysis metrics, cortical thickness, volume, surface area, and local gyrification index (LGI), in different stages of AD-related cognitive decline. Participants with normal cognition, mild cognitive impairment, and AD were included (34 participants per group). All undertook the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) battery of neuropsychological tests and brain MRI scanning. We analyzed associations between morphometric measures and CERAD total/Mini Mental State Examination (MMSE) scores for the regions of interest (ROIs), identifying three types of curves: U-shaped, inverted U-shaped, and linear. Cortical thickness and volume analyses showed linear types in most of the significant ROIs. Significant ROIs for the cortical thickness analysis were located in the temporal and limbic lobes, whereas those for volume and surface area were distributed over more diffuse areas of the brain. LGI analysis showed few significant ROIs. CERAD total scores were more sensitive to early changes of cortical structures than MMSE scores. Cortical thickness analysis may be preferable in assessing brain structural MRI changes during AD-related cognitive decline, whereas LGI analysis may have limited capability to reflect the cognitive decrease. Our findings may provide a reference for future studies and help to establish optimal analytical approaches to brain structural MRI in neurodegenerative diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | SURFACE-BASED ANALYSIS | - |
dc.subject | HUMAN CEREBRAL-CORTEX | - |
dc.subject | CORTICAL THICKNESS | - |
dc.subject | NEUROPSYCHOLOGICAL ASSESSMENT | - |
dc.subject | NEUROFIBRILLARY TANGLES | - |
dc.subject | DISEASE | - |
dc.subject | DECLINE | - |
dc.subject | VOLUME | - |
dc.subject | CERAD | - |
dc.subject | AREA | - |
dc.title | Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer's dementia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Sangil | - |
dc.contributor.affiliatedAuthor | Seong, Joon-Kyung | - |
dc.contributor.affiliatedAuthor | Jeong, Hyun-Ghang | - |
dc.contributor.affiliatedAuthor | Han, Cheol E. | - |
dc.identifier.doi | 10.1371/journal.pone.0220739 | - |
dc.identifier.scopusid | 2-s2.0-85070947176 | - |
dc.identifier.wosid | 000484987900082 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.14, no.8 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 14 | - |
dc.citation.number | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SURFACE-BASED ANALYSIS | - |
dc.subject.keywordPlus | HUMAN CEREBRAL-CORTEX | - |
dc.subject.keywordPlus | CORTICAL THICKNESS | - |
dc.subject.keywordPlus | NEUROPSYCHOLOGICAL ASSESSMENT | - |
dc.subject.keywordPlus | NEUROFIBRILLARY TANGLES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | DECLINE | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | CERAD | - |
dc.subject.keywordPlus | AREA | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.