Significance of Differential Characteristics in Infantile Kawasaki Disease
DC Field | Value | Language |
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dc.contributor.author | Kwak, Ji Hee | - |
dc.contributor.author | Lee, JungHwa | - |
dc.contributor.author | Ha, Kee Soo | - |
dc.date.accessioned | 2021-09-01T10:05:31Z | - |
dc.date.available | 2021-09-01T10:05:31Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/63614 | - |
dc.description.abstract | Background and Objectives: Immunological variability in Kawasaki disease (KD) shows age-specific differences; however, specific differences in laboratory values have not been compared between infants and non-infants with KD. We compared age-adjusted Z-values (Z) of white and red blood cells in infants with KD with those in non-infants with KD. Methods: This study retrospectively investigated 192 infants and 667 non-infants recruited between 2003 and 2015 at the Korea University Hospital. Laboratory values for infants with KD and non-infants with KD were analyzed and age-unadjusted raw values (R) and age-adjusted Z for blood cells counts were determined. Results: Z in infants with KD during pre-intravenous immunoglobulin (IVIG), post-IVIG, and chronic phases showed increased lymphopenia and eosinophilia, low neutrophil: lymphocyte and neutrophil: eosinophil ratios, worse anemia, increased thrombocytosis, and reduced erythrocyte sedimentation rates compared with those in non-infants with KD. The optimal cut-off value for pre-IVIG Z-hemoglobin for prediction of KD in all patients was <-0.01 (area under the curve [AUC], 0.914; sensitivity/specificity, 0.999/0.886; p=0.04). The optimal cutoff value for pre-IVIG C-reactive protein (CRP) for prediction of KD in infants compared to that in febrile control infants was >40 mg/L (AUC, 0.811; sensitivity/specificity, 0.712/0.700; p=0.04). Conclusions: Laboratory characteristics enable differentiation between infants and non-infants with KD and contribute to a better understanding of changes in blood cell counts. Infants with incomplete KD can be more easily differentiated from infants with simple febrile illness using pre-IVIG Z-hemoglobin and pre-IVIG CRP values. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC CARDIOLOGY | - |
dc.subject | PERIPHERAL-BLOOD EOSINOPHILIA | - |
dc.subject | LYMPH-NODE SYNDROME | - |
dc.subject | INTRAVENOUS IMMUNOGLOBULIN | - |
dc.subject | DIAGNOSIS | - |
dc.subject | MANAGEMENT | - |
dc.subject | CHILDREN | - |
dc.title | Significance of Differential Characteristics in Infantile Kawasaki Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ha, Kee Soo | - |
dc.identifier.doi | 10.4070/kcj.2018.0434 | - |
dc.identifier.scopusid | 2-s2.0-85072282090 | - |
dc.identifier.wosid | 000477872700011 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, v.49, no.8, pp.755 - 765 | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.citation.title | KOREAN CIRCULATION JOURNAL | - |
dc.citation.volume | 49 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 755 | - |
dc.citation.endPage | 765 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002489774 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD EOSINOPHILIA | - |
dc.subject.keywordPlus | LYMPH-NODE SYNDROME | - |
dc.subject.keywordPlus | INTRAVENOUS IMMUNOGLOBULIN | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordAuthor | Kawasaki disease | - |
dc.subject.keywordAuthor | Infant | - |
dc.subject.keywordAuthor | Differential leukocyte count | - |
dc.subject.keywordAuthor | Hemoglobin | - |
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