Associations between paraoxonase 1 (PON1) polymorphisms and susceptibility and PON1 activity in rheumatoid arthritis patients, and comparison of PON1 activity in patients and controls: a meta-analysis

Abstract

ObjectivesWe reviewed the associations between paraoxonase 1 (PON1) polymorphisms and susceptibility and PON1 activity in rheumatoid arthritis (RA) patients and compared PON1 activity between RA patients and controls.MethodsWe conducted a meta-analysis of PON1 Q192R and L55M polymorphism and RA risk data and determined the associations between PON1 Q192R polymorphism and PON1 activity in RA patients. We also compared serum/plasma PON1 activity levels in RA patients and controls.ResultsTwelve studies were included in this meta-analysis. No association was observed between RA and the PON1 192R allele in any study subject (OR=0.967, 95% CI=0.829-1.129, p=0.674). Analysis using recessive, dominant, or homozygous contrast models revealed no association between the PON1 192R allele and RA. Meta-analysis showed no association between RA and the PON1 55M allele (OR=1.400, 95% CI=0.738-2.658, p=0.308). In the meta-analysis, PON1 activity was significantly higher in the RR genotype than in the QQ (SMD=2.975, 95% CI=2.157-3.792, p<0.001) and QR (SMD=1.265, 95% CI=0.898-1.633, p<0.001) genotypes. PON1 activity was significantly lower in the RA group than in the control group (SMD=-3.176, 95% CI=-5.070 to -1.283, p<0.001).ConclusionsWe found no association between the PON1 Q192R and L55M polymorphisms and susceptibility to RA, while PON1 Q192R polymorphism was associated with PON1 activity in RA patients; we found significantly lower PON1 activity in RA patients.