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Butyric acid production with high selectivity coupled with acetic acid consumption in sugar-glycerol mixture fermentation by Clostridium tyrobutyricum ATCC25755

Authors
Oh, Hyun JuKim, Ki-YeonLee, Kyung MinLee, Sun-MiGong, GyeongtaekOh, Min-KyuUm, Youngsoon
Issue Date
25-7월-2019
Publisher
ELSEVIER SCIENCE INC
Keywords
Clostridium tyrobutyricumATCC 25755; Butyric acid; Glycerol; Glucose; Acetic acid reassimilation
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.75, pp.44 - 51
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume
75
Start Page
44
End Page
51
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/64060
DOI
10.1016/j.jiec.2019.01.047
ISSN
1226-086X
Abstract
Butyric acid-producing strain Clostridium tyrobutyricum ATCC25755 produces acetic acid as a byproduct, which lowers butyric acid yield and selectivity. Supplementing glycerol would be a rational approach to enhance a NADH-requiring metabolite butyric acid selectivity by increasing NADH availability; however, there has been no report butyric acid production using glycerol as either a sole carbon source or a co-substrate with C. tyrobutyricum. In this study, glycerol was supplemented along with sugar to increase NADH availability facilitating the production of butyric acid. C. tyrobutyricum was found to simultaneously consume glucose and glycerol only when acetic acid was present. Notably, acetic acid was not produced but consumed. The amount of glycerol consumption was linearly dependent on the amount of acetic acid consumption. When mixed sugars (glucose 80 g/L and xylose 30 g/L) and crude glycerol were used, not only exogenous acetic acid consumption but also acetic acid reassimilation were clearly observed, resulting in significantly enhanced butyric acid production (54.79 g/L), yield (0.464 g/g), and selectivity (98.3%) compared to sugar-only fermentation (production, 35.42 g/L; yield, 0.339 g/g; selectivity, 69.1%). Therefore, this study would pave the way for selective and cost-effective butyric acid production using sugars and glycerol from biodiesel facility. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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