Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy
DC Field | Value | Language |
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dc.contributor.author | Hada, Manila | - |
dc.contributor.author | Oh, Hannah | - |
dc.contributor.author | Pfeiffer, Ruth M. | - |
dc.contributor.author | Falk, Roni T. | - |
dc.contributor.author | Fan, Shaoqi | - |
dc.contributor.author | Mullooly, Maeve | - |
dc.contributor.author | Pollak, Michael | - |
dc.contributor.author | Geller, Berta | - |
dc.contributor.author | Vacek, Pamela M. | - |
dc.contributor.author | Weaver, Donald | - |
dc.contributor.author | Shepherd, John | - |
dc.contributor.author | Wang, Jeff | - |
dc.contributor.author | Fan, Bo | - |
dc.contributor.author | Mahmoudzadeh, Amir Pasha | - |
dc.contributor.author | Malkov, Serghei | - |
dc.contributor.author | Herschorn, Sally | - |
dc.contributor.author | Brinton, Louise A. | - |
dc.contributor.author | Sherman, Mark E. | - |
dc.contributor.author | Gierach, Gretchen L. | - |
dc.date.accessioned | 2021-09-01T11:27:49Z | - |
dc.date.available | 2021-09-01T11:27:49Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-07-23 | - |
dc.identifier.issn | 1465-5411 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64074 | - |
dc.description.abstract | BackgroundMammographic density (MD) is a strong breast cancer risk factor that reflects fibroglandular and adipose tissue composition, but its biologic underpinnings are poorly understood. Insulin-like growth factor binding proteins (IGFBPs) are markers that may be associated with MD given their hypothesized role in breast carcinogenesis. IGFBPs sequester IGF-I, limiting its bioavailability. Prior studies have found positive associations between circulating IGF-I and the IGF-I:IGFBP-3 ratio and breast cancer risk. We evaluated the associations of IGF-I, IGFBP-3, and six other IGFBPs with MD.MethodsSerum IGF measures were quantified in 296 women, ages 40-65, undergoing diagnostic image-guided breast biopsy. Volumetric density measures (MD-V) were assessed in pre-biopsy digital mammograms using single X-ray absorptiometry. Area density measures (MD-A) were estimated by computer-assisted thresholding software. Age, body mass index (BMI), and BMI2-adjusted linear regression models were used to examine associations of serum IGF measures with MD. Effect modification by BMI was also assessed.ResultsIGF-I and IGFBP-3 were not strongly associated with MD after BMI adjustment. In multivariable analyses among premenopausal women, IGFBP-2 was positively associated with both percent MD-V (beta=1.49, p value=0.02) and MD-A (beta=1.55, p value=0.05). Among postmenopausal women, positive relationships between IGFBP-2 and percent MD-V (beta=2.04, p=0.003) were observed; the positive associations between IGFBP-2 and percent MD-V were stronger among lean women (BMI<25kg/m(2)) (beta=5.32, p=0.0002; p interaction=0.0003).ConclusionsIn this comprehensive study of IGFBPs and MD, we observed a novel positive association between IGFBP-2 and MD, particularly among women with lower BMI. In concert with in vitro studies suggesting a dual role of IGFBP-2 on breast tissue, promoting cell proliferation as well as inhibiting tumorigenesis, our findings suggest that further studies assessing the role of IGFBP-2 in breast tissue composition, in addition to IGF-1 and IGFBP-3, are warranted. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | IGF-I | - |
dc.subject | CANCER RISK | - |
dc.subject | LIFE-STYLE | - |
dc.subject | INDIVIDUAL DATA | - |
dc.subject | ASSOCIATION | - |
dc.subject | IGFBP-3 | - |
dc.subject | HORMONE | - |
dc.subject | ALCOHOL | - |
dc.subject | SYSTEM | - |
dc.title | Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Hannah | - |
dc.identifier.doi | 10.1186/s13058-019-1162-8 | - |
dc.identifier.scopusid | 2-s2.0-85069764274 | - |
dc.identifier.wosid | 000477050700001 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH, v.21 | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH | - |
dc.citation.title | BREAST CANCER RESEARCH | - |
dc.citation.volume | 21 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | IGF-I | - |
dc.subject.keywordPlus | CANCER RISK | - |
dc.subject.keywordPlus | LIFE-STYLE | - |
dc.subject.keywordPlus | INDIVIDUAL DATA | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | IGFBP-3 | - |
dc.subject.keywordPlus | HORMONE | - |
dc.subject.keywordPlus | ALCOHOL | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordAuthor | Mammographic density | - |
dc.subject.keywordAuthor | Breast density | - |
dc.subject.keywordAuthor | Insulin-like growth factor | - |
dc.subject.keywordAuthor | Insulin-like growth factor binding proteins | - |
dc.subject.keywordAuthor | Breast neoplasm | - |
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