MoS2 Field-Effect Transistor-Amyloid-beta(1-42) Hybrid Device for Signal Amplified Detection of MMP-9
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Heekyeong | - |
dc.contributor.author | Lee, Hyungbeen | - |
dc.contributor.author | Jeong, Seok Hwan | - |
dc.contributor.author | Lee, Eunjin | - |
dc.contributor.author | Lee, Wonseok | - |
dc.contributor.author | Liu, Na | - |
dc.contributor.author | Yoon, Dae Sung | - |
dc.contributor.author | Kim, Sunkook | - |
dc.contributor.author | Lee, Sang Woo | - |
dc.date.accessioned | 2021-09-01T12:23:50Z | - |
dc.date.available | 2021-09-01T12:23:50Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-07-02 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64158 | - |
dc.description.abstract | The detection of circulating protein (CP) is very important for the diagnosis and therapeutics of cancer. Conventional techniques based on a specific antibody-antigen interaction are still lacking because of a shortage of cost effectiveness, complicated sandwich structure and tagging process, and inconsistent detection of CP due to the inherent instability of antibodies. Herein, we demonstrate a hybrid device consisting of two-dimensional (2D) nanoscale molybdenum disulfide (MoS2) field-effect transistor (FET) with an amyloid-beta(1-42) (A beta(1-42)) functionalized surface, which amplifies electric signals of the FET in order to detect matrix metalloproteinase-9 (MMP-9), which is a certain type of CP that degrades A beta(1-42). With the hybrid device, we detected the concentrations of MMP-9 in the range from 1 pM to 10 nM. Moreover, using tapping-mode atomic force microscopy and Kelvin probe force microscopy, we verified that the signal amplification corresponding to the MMP-9 concentrations was caused by the reduced length and the decreased surface potential of degraded A beta(1-42) due to MMP-9. The hybrid device studied in this paper can be very useful for monitoring MMP-9 activity, as well as serving as a sensing platform for the electrical signal amplification of 2D MoS2 FET-biosensors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | LABEL-FREE | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | EFFECT TRANSISTOR | - |
dc.subject | GRAPHENE OXIDE | - |
dc.subject | CANCER | - |
dc.subject | BIOSENSOR | - |
dc.subject | EXPRESSION | - |
dc.subject | STABILITY | - |
dc.subject | SERUM | - |
dc.subject | XPS | - |
dc.title | MoS2 Field-Effect Transistor-Amyloid-beta(1-42) Hybrid Device for Signal Amplified Detection of MMP-9 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Dae Sung | - |
dc.identifier.doi | 10.1021/acs.analchem.9b00926 | - |
dc.identifier.scopusid | 2-s2.0-85069264715 | - |
dc.identifier.wosid | 000474477900039 | - |
dc.identifier.bibliographicCitation | ANALYTICAL CHEMISTRY, v.91, no.13, pp.8252 - 8258 | - |
dc.relation.isPartOf | ANALYTICAL CHEMISTRY | - |
dc.citation.title | ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 91 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 8252 | - |
dc.citation.endPage | 8258 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | LABEL-FREE | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | EFFECT TRANSISTOR | - |
dc.subject.keywordPlus | GRAPHENE OXIDE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | XPS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.