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Rapid and Efficient Separation of Decursin and Decursinol Angelate from Angelica gigas Nakai using Ionic Liquid, (BMIm)BF4, Combined with Crystallization

Authors
Kiyonga, Alice NguvokoAn, Ji-HunLee, Ki YongLim, ChangjinSuh, Young-GerChin, Young-WonJung, Kiwon
Issue Date
1-7월-2019
Publisher
MDPI
Keywords
ionic liquids; decursin; decursinol angelate; Angelica gigas Nakai; crystallization
Citation
MOLECULES, v.24, no.13
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
24
Number
13
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/64179
DOI
10.3390/molecules24132390
ISSN
1420-3049
Abstract
Ionic liquids (ILs) have gained much attention as alternative solvents to volatile organic solvents due to their attractive properties. This study aimed to develop an efficient method for the selective separation of decursin (D) and decursinol angelate (DA) from Angelica gigas Nakai (A. gigas) using ILs and crystallization. The IL 1-butyl-3-methylimidazolium tetrafluoroborate ((BMIm)BF4) was the most efficient at extracting D and DA. Parameters including solid-to-liquid ratio, time, and temperature were optimized by response surface methodology (RSM). Under optimal extraction conditions (1 g/6.5 mL solid-to-liquid ratio, 60 degrees C temperature, and 120 min time), the extraction yields of D and DA were 43.32 mg/g (97.06%) and 17.87 mg/g (97.12%), respectively. Moreover, drowning out crystallization using deionized water (DW) as an anti-solvent offered an excellent ability to recover D and DA from the A. gigas-(BMIm)BF4 extraction solution. The rates of recovery and the total purity of D and DA were found to be greater than 97%. Therefore, a rapid and efficient method of combining ILs with crystallization was effectively achieved for the selective separation of D and DA. This approach is assumed to be beneficial in the pharmaceutical industry for the effective obtention of D- and DA-enriched products.
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