Causal relationship between years of education and the occurrence of rheumatoid arthritis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-01T12:53:23Z | - |
dc.date.available | 2021-09-01T12:53:23Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 0032-5473 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64258 | - |
dc.description.abstract | Objective To search out whether or not years of education is causally related to rheumatoid arthritis (RA). Method We conducted a two-sample Mendelian randomisation (MR) analysis employing inverse-variance weighted (IVW), weighted median and MR-Egger regression analysis. We chose statistic data of years of education from the UK Biobank genome-wide association studies (GWASs) (n=293 723) as the exposure and a meta-analysis of GWASs of RA with autoantibody (n=5539) and European controls (n=20 169) as the outcome. Results We selected a total of 49 single nucleotide polymorphisms as instrumental variables (IVs). The IVW method instructed an inverse causative relationship between years of education and RA (beta=- 0.039, SE=0.283, p=0.008). MR-Egger regression test showed that directional pleiotropy seems not to bias the MR results (intercept=0.028; p=0.358). MR-Egger analysis demonstrated no causative relationship between RA and years of education (beta=- 2.320, SE=1.709, p=0.181). However, the weighted median approach indicated a causative association between RA and years of education (beta=-0.950, SE=0.355, p=0.008). Conclusions The MR analysis supported a potential inverse causative relationship between years of education and development of RA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | MENDELIAN RANDOMIZATION | - |
dc.subject | GENETIC-VARIANTS | - |
dc.subject | FORMAL EDUCATION | - |
dc.subject | MORTALITY | - |
dc.subject | RISK | - |
dc.title | Causal relationship between years of education and the occurrence of rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1136/postgradmedj-2018-136374 | - |
dc.identifier.scopusid | 2-s2.0-85066885360 | - |
dc.identifier.wosid | 000475957400004 | - |
dc.identifier.bibliographicCitation | POSTGRADUATE MEDICAL JOURNAL, v.95, no.1125, pp.378 - 381 | - |
dc.relation.isPartOf | POSTGRADUATE MEDICAL JOURNAL | - |
dc.citation.title | POSTGRADUATE MEDICAL JOURNAL | - |
dc.citation.volume | 95 | - |
dc.citation.number | 1125 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 381 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | MENDELIAN RANDOMIZATION | - |
dc.subject.keywordPlus | GENETIC-VARIANTS | - |
dc.subject.keywordPlus | FORMAL EDUCATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | mendelian randomization | - |
dc.subject.keywordAuthor | educational attainment | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
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