Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment
DC Field | Value | Language |
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dc.contributor.author | Jang, Soomin | - |
dc.contributor.author | Han, Ji Won | - |
dc.contributor.author | Shin, Jiyoon | - |
dc.contributor.author | Kim, Tae Hui | - |
dc.contributor.author | Kwak, Kyung Phil | - |
dc.contributor.author | Kim, Kayoung | - |
dc.contributor.author | Kim, Bong Jo | - |
dc.contributor.author | Kim, Shin Gyeom | - |
dc.contributor.author | Kim, Jeong Lan | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Moon, Seok Woo | - |
dc.contributor.author | Park, Jae Young | - |
dc.contributor.author | Park, Joon Hyuk | - |
dc.contributor.author | Byun, Seonjeong | - |
dc.contributor.author | Suh, Seung Wan | - |
dc.contributor.author | Seo, Jiyeong | - |
dc.contributor.author | So, Yoonseop | - |
dc.contributor.author | Ryu, Seung-Ho | - |
dc.contributor.author | Youn, Jong Chul | - |
dc.contributor.author | Lee, Kyoung Hwan | - |
dc.contributor.author | Lee, Dong Young | - |
dc.contributor.author | Lee, Dong Woo | - |
dc.contributor.author | Lee, Seok Bum | - |
dc.contributor.author | Lee, Jung Jae | - |
dc.contributor.author | Lee, Ju Ri | - |
dc.contributor.author | Jeong, Hyeon | - |
dc.contributor.author | Jeong, Hyun-Ghang | - |
dc.contributor.author | Jhoo, Jin Hyeong | - |
dc.contributor.author | Han, Kyuhee | - |
dc.contributor.author | Hong, Jong Woo | - |
dc.contributor.author | Kim, Ki Woong | - |
dc.date.accessioned | 2021-09-01T12:55:22Z | - |
dc.date.available | 2021-09-01T12:55:22Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64276 | - |
dc.description.abstract | Objective This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. Methods We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the "Korean Longitudinal Study on Cognitive Aging and Dementia." The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. Results The lowest quartile group of serum folate (>= 1.5, <= 5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031). Conclusion Normal-but-low serum folate levels were associated with the risk of cognitive disorders in the elderly population, and a decline to normal-but-low serum folate levels was associated with incident dementia. Maintaining serum folate concentration above 5.9 ng/mL may be beneficial for cognitive status. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROPSYCHIATRIC ASSOC | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | KOREAN VERSION | - |
dc.subject | FOLIC-ACID | - |
dc.subject | ASSESSMENT BATTERY | - |
dc.subject | TOTAL HOMOCYSTEINE | - |
dc.subject | VITAMIN-B-12 | - |
dc.subject | DEMENTIA | - |
dc.subject | CONTROVERSIES | - |
dc.subject | TOXICITY | - |
dc.title | Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, Hyun-Ghang | - |
dc.identifier.doi | 10.30773/pi.2019.05.29 | - |
dc.identifier.scopusid | 2-s2.0-85071672476 | - |
dc.identifier.wosid | 000477735200007 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, v.16, no.7, pp.532 - 538 | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.citation.title | PSYCHIATRY INVESTIGATION | - |
dc.citation.volume | 16 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 532 | - |
dc.citation.endPage | 538 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002488920 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | FOLIC-ACID | - |
dc.subject.keywordPlus | ASSESSMENT BATTERY | - |
dc.subject.keywordPlus | TOTAL HOMOCYSTEINE | - |
dc.subject.keywordPlus | VITAMIN-B-12 | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | CONTROVERSIES | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | Folate | - |
dc.subject.keywordAuthor | Elderly | - |
dc.subject.keywordAuthor | Cognition | - |
dc.subject.keywordAuthor | Dementia | - |
dc.subject.keywordAuthor | Cohort studies | - |
dc.subject.keywordAuthor | Longitudinal studies | - |
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