DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury
DC Field | Value | Language |
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dc.contributor.author | Shin, Jung Eun | - |
dc.contributor.author | Ha, Hongseok | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.contributor.author | Cho, Yongcheol | - |
dc.contributor.author | DiAntonio, Aaron | - |
dc.date.accessioned | 2021-09-01T13:22:04Z | - |
dc.date.available | 2021-09-01T13:22:04Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64592 | - |
dc.description.abstract | Following damage to a peripheral nerve, injury signaling pathways converge in the cell body to generate transcriptional changes that support axon regeneration. Here, we demonstrate that dual leucine zipper kinase (DLK), a central regulator of injury responses including axon regeneration and neuronal apoptosis, is required for the induction of the pro-regenerative transcriptional program in response to peripheral nerve injury. Using a sensory neuron-conditional DLK knockout mouse model, we show a time course for the dependency of gene expression changes on the DLK pathway after sciatic nerve injury. Gene ontology analysis reveals that DLK-dependent gene sets are enriched for specific functional annotations such as ion transport and immune response. A series of comparative analyses shows that the DLK-dependent transcriptional program is distinct from that promoted by the importin-dependent retrograde signaling pathway, while it is partially shared between PNS and CNS injury responses. We suggest that DLK-dependency might provide a selective filter for regeneration-associated genes among the injury-responsive transcriptome. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | LEUCINE-ZIPPER KINASE | - |
dc.subject | AXON SELF-DESTRUCTION | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | BEARING KINASE | - |
dc.subject | GROWTH | - |
dc.subject | ADULT | - |
dc.subject | NEURONS | - |
dc.subject | JNK | - |
dc.subject | AXOTOMY | - |
dc.subject | STRESS | - |
dc.title | DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Jung Eun | - |
dc.contributor.affiliatedAuthor | Ha, Hongseok | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.contributor.affiliatedAuthor | Cho, Yongcheol | - |
dc.identifier.doi | 10.1016/j.nbd.2019.02.001 | - |
dc.identifier.scopusid | 2-s2.0-85062715690 | - |
dc.identifier.wosid | 000472990100015 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF DISEASE, v.127, pp.178 - 192 | - |
dc.relation.isPartOf | NEUROBIOLOGY OF DISEASE | - |
dc.citation.title | NEUROBIOLOGY OF DISEASE | - |
dc.citation.volume | 127 | - |
dc.citation.startPage | 178 | - |
dc.citation.endPage | 192 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | LEUCINE-ZIPPER KINASE | - |
dc.subject.keywordPlus | AXON SELF-DESTRUCTION | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | BEARING KINASE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | ADULT | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordPlus | AXOTOMY | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordAuthor | Dual leucine zipper kinase | - |
dc.subject.keywordAuthor | Conditioning injury | - |
dc.subject.keywordAuthor | Axon regeneration | - |
dc.subject.keywordAuthor | Neuroinflammation | - |
dc.subject.keywordAuthor | Neurodegeneration | - |
dc.subject.keywordAuthor | Pain | - |
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