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Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors

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dc.contributor.authorPark, Bernie Byunghoon-
dc.contributor.authorChoi, Jae Wan-
dc.contributor.authorPark, Dawon-
dc.contributor.authorChoi, Doyoung-
dc.contributor.authorPaek, Jiwon-
dc.contributor.authorKim, Hyun Jung-
dc.contributor.authorSon, Se-Young-
dc.contributor.authorUl Mushtaq, Ameeq-
dc.contributor.authorShin, Hyeji-
dc.contributor.authorKim, Sang Hoon-
dc.contributor.authorZhou, Yuanyuan-
dc.contributor.authorLim, Taehyeong-
dc.contributor.authorPark, Ji Young-
dc.contributor.authorBaek, Ji-Young-
dc.contributor.authorKim, Kyul-
dc.contributor.authorKwon, Hongmok-
dc.contributor.authorSon, Sang-Hyun-
dc.contributor.authorChung, Ka Young-
dc.contributor.authorJeong, Hyun-Ja-
dc.contributor.authorKim, Hyung-Min-
dc.contributor.authorJung, Yong Woo-
dc.contributor.authorLee, Kiho-
dc.contributor.authorLee, Ki Yong-
dc.contributor.authorByun, Youngjoo-
dc.contributor.authorJeon, Young Ho-
dc.date.accessioned2021-09-01T13:40:21Z-
dc.date.available2021-09-01T13:40:21Z-
dc.date.created2021-06-19-
dc.date.issued2019-06-19-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/64748-
dc.description.abstractThymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting in eosinophilic inflammation and numerous allergic diseases. Baicalein (1), a major component of Scutellaria baicalensis, was found to be the first small molecule to block TSLP signaling pathways. It inhibited effectively eosinophil infiltration in house dust mite-induced and ovalbumin-challenged mouse models. Structure-activity relationship studies identified compound 11a, a biphenyl flavanone analog, as a novel human TSLP inhibitor for the discovery and development of new anti-allergic drugs.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectTHYMIC STROMAL LYMPHOPOIETIN-
dc.subjectINNATE LYMPHOID-CELLS-
dc.subjectBIOLOGICAL EVALUATION-
dc.subjectTYPE-2 IMMUNITY-
dc.subjectDERIVATIVES-
dc.subjectFLAVONOIDS-
dc.subjectCYTOKINE-
dc.subjectBINDING-
dc.subjectINFLAMMATION-
dc.subjectCHALCONES-
dc.titleStructure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors-
dc.typeArticle-
dc.contributor.affiliatedAuthorJung, Yong Woo-
dc.contributor.affiliatedAuthorLee, Kiho-
dc.contributor.affiliatedAuthorLee, Ki Yong-
dc.contributor.affiliatedAuthorByun, Youngjoo-
dc.contributor.affiliatedAuthorJeon, Young Ho-
dc.identifier.doi10.1038/s41598-019-44853-5-
dc.identifier.scopusid2-s2.0-85068401290-
dc.identifier.wosid000472029100041-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.9-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume9-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusTHYMIC STROMAL LYMPHOPOIETIN-
dc.subject.keywordPlusINNATE LYMPHOID-CELLS-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusTYPE-2 IMMUNITY-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusCYTOKINE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusCHALCONES-
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