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Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

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dc.contributor.authorMenden, Michael P.-
dc.contributor.authorWang, Dennis-
dc.contributor.authorMason, Mike J.-
dc.contributor.authorSzalai, Bence-
dc.contributor.authorBulusu, Krishna C.-
dc.contributor.authorGuan, Yuanfang-
dc.contributor.authorYu, Thomas-
dc.contributor.authorKang, Jaewoo-
dc.contributor.authorJeon, Minji-
dc.contributor.authorWolfinger, Russ-
dc.contributor.authorNguyen, Tin-
dc.contributor.authorZaslavskiy, Mikhail-
dc.contributor.authorJang, In Sock-
dc.contributor.authorGhazoui, Zara-
dc.contributor.authorAhsen, Mehmet Eren-
dc.contributor.authorVogel, Robert-
dc.contributor.authorNeto, Elias Chaibub-
dc.contributor.authorNorman, Thea-
dc.contributor.authorTang, Eric K. Y.-
dc.contributor.authorGarnett, Mathew J.-
dc.contributor.authorDi Veroli, Giovanni Y.-
dc.contributor.authorFawell, Stephen-
dc.contributor.authorStolovitzky, Gustavo-
dc.contributor.authorGuinney, Justin-
dc.contributor.authorDry, Jonathan R.-
dc.contributor.authorSaez-Rodriguez, Julio-
dc.contributor.authorAbante, Jordi-
dc.contributor.authorAbecassis, Barbara Schmitz-
dc.contributor.authorAben, Nanne-
dc.contributor.authorAghamirzaie, Delasa-
dc.contributor.authorAittokallio, Tero-
dc.contributor.authorAkhtari, Farida S.-
dc.contributor.authorAl-lazikani, Bissan-
dc.contributor.authorAlam, Tanvir-
dc.contributor.authorAllam, Amin-
dc.contributor.authorAllen, Chad-
dc.contributor.authorde Almeida, Mariana Pelicano-
dc.contributor.authorAltarawy, Doaa-
dc.contributor.authorAlves, Vinicius-
dc.contributor.authorAmadoz, Alicia-
dc.contributor.authorAnchang, Benedict-
dc.contributor.authorAntolin, Albert A.-
dc.contributor.authorAsh, Jeremy R.-
dc.contributor.authorRomeo Aznar, Victoria-
dc.contributor.authorBa-alawi, Wail-
dc.contributor.authorBagheri, Moeen-
dc.contributor.authorBajic, Vladimir-
dc.contributor.authorBall, Gordon-
dc.contributor.authorBallester, Pedro J.-
dc.contributor.authorBaptista, Delora-
dc.contributor.authorBare, Christopher-
dc.contributor.authorBateson, Mathilde-
dc.contributor.authorBender, Andreas-
dc.contributor.authorBertrand, Denis-
dc.contributor.authorWijayawardena, Bhagya-
dc.contributor.authorBoroevich, Keith A.-
dc.contributor.authorBosdriesz, Evert-
dc.contributor.authorBougouffa, Salim-
dc.contributor.authorBounova, Gergana-
dc.contributor.authorBrouwer, Thomas-
dc.contributor.authorBryant, Barbara-
dc.contributor.authorCalaza, Manuel-
dc.contributor.authorCalderone, Alberto-
dc.contributor.authorCalza, Stefano-
dc.contributor.authorCapuzzi, Stephen-
dc.contributor.authorCarbonell-Caballero, Jose-
dc.contributor.authorCarlin, Daniel-
dc.contributor.authorCarter, Hannah-
dc.contributor.authorCastagnoli, Luisa-
dc.contributor.authorCelebi, Remzi-
dc.contributor.authorCesareni, Gianni-
dc.contributor.authorChang, Hyeokyoon-
dc.contributor.authorChen, Guocai-
dc.contributor.authorChen, Haoran-
dc.contributor.authorChen, Huiyuan-
dc.contributor.authorCheng, Lijun-
dc.contributor.authorChernomoretz, Ariel-
dc.contributor.authorChicco, Davide-
dc.contributor.authorCho, Kwang-Hyun-
dc.contributor.authorCho, Sunghwan-
dc.contributor.authorChoi, Daeseon-
dc.contributor.authorChoi, Jaejoon-
dc.contributor.authorChoi, Kwanghun-
dc.contributor.authorChoi, Minsoo-
dc.contributor.authorDe Cock, Martine-
dc.contributor.authorCoker, Elizabeth-
dc.contributor.authorCortes-Ciriano, Isidro-
dc.contributor.authorCserzo, Miklos-
dc.contributor.authorCubuk, Cankut-
dc.contributor.authorCurtis, Christina-
dc.contributor.authorVan Daele, Dries-
dc.contributor.authorDang, Cuong C.-
dc.contributor.authorDijkstra, Tjeerd-
dc.contributor.authorDopazo, Joaquin-
dc.contributor.authorDraghici, Sorin-
dc.contributor.authorDrosou, Anastasios-
dc.contributor.authorDumontier, Michel-
dc.contributor.authorEhrhart, Friederike-
dc.contributor.authorEid, Fatma-Elzahraa-
dc.contributor.authorElHefnawi, Mahmoud-
dc.contributor.authorElmarakeby, Haitham-
dc.contributor.authorvan Engelen, Bo-
dc.contributor.authorEngin, Hatice Billur-
dc.contributor.authorde Esch, Iwan-
dc.contributor.authorEvelo, Chris-
dc.contributor.authorFalcao, Andre O.-
dc.contributor.authorFarag, Sherif-
dc.contributor.authorFernandez-Lozano, Carlos-
dc.contributor.authorFisch, Kathleen-
dc.contributor.authorFlobak, Asmund-
dc.contributor.authorFornari, Chiara-
dc.contributor.authorForoushani, Amir B. K.-
dc.contributor.authorFotso, Donatien Chedom-
dc.contributor.authorFourches, Denis-
dc.contributor.authorFriend, Stephen-
dc.contributor.authorFrigessi, Arnoldo-
dc.contributor.authorGao, Feng-
dc.contributor.authorGao, Xiaoting-
dc.contributor.authorGerold, Jeffrey M.-
dc.contributor.authorGestraud, Pierre-
dc.contributor.authorGhosh, Samik-
dc.contributor.authorGillberg, Jussi-
dc.contributor.authorGodoy-Lorite, Antonia-
dc.contributor.authorGodynyuk, Lizzy-
dc.contributor.authorGodzik, Adam-
dc.contributor.authorGoldenberg, Anna-
dc.contributor.authorGomez-Cabrero, David-
dc.contributor.authorGonen, Mehmet-
dc.contributor.authorde Graaf, Chris-
dc.contributor.authorGray, Harry-
dc.contributor.authorGrechkin, Maxim-
dc.contributor.authorGuimera, Roger-
dc.contributor.authorGuney, Emre-
dc.contributor.authorHaibe-Kains, Benjamin-
dc.contributor.authorHan, Younghyun-
dc.contributor.authorHase, Takeshi-
dc.contributor.authorHe, Di-
dc.contributor.authorHe, Liye-
dc.contributor.authorHeath, Lenwood S.-
dc.contributor.authorHellton, Kristoffer H.-
dc.contributor.authorHelmer-Citterich, Manuela-
dc.contributor.authorHidalgo, Marta R.-
dc.contributor.authorHidru, Daniel-
dc.contributor.authorHill, Steven M.-
dc.contributor.authorHochreiter, Sepp-
dc.contributor.authorHong, Seungpyo-
dc.contributor.authorHovig, Eivind-
dc.contributor.authorHsueh, Ya-Chih-
dc.contributor.authorHu, Zhiyuan-
dc.contributor.authorHuang, Justin K.-
dc.contributor.authorHuang, R. Stephanie-
dc.contributor.authorHunyady, Laszlo-
dc.contributor.authorHwang, Jinseub-
dc.contributor.authorHwang, Tae Hyun-
dc.contributor.authorHwang, Woochang-
dc.contributor.authorHwang, Yongdeuk-
dc.contributor.authorIsayev, Olexandr-
dc.contributor.authorWalk, Oliver Bear Don't-
dc.contributor.authorJack, John-
dc.contributor.authorJahandideh, Samad-
dc.contributor.authorJi, Jiadong-
dc.contributor.authorJo, Yousang-
dc.contributor.authorKamola, Piotr J.-
dc.contributor.authorKanev, Georgi K.-
dc.contributor.authorKaracosta, Loukia-
dc.contributor.authorKarimi, Mostafa-
dc.contributor.authorKaski, Samuel-
dc.contributor.authorKazanov, Marat-
dc.contributor.authorKhamis, Abdullah M.-
dc.contributor.authorKhan, Suleiman Ali-
dc.contributor.authorKiani, Narsis A.-
dc.contributor.authorKim, Allen-
dc.contributor.authorKim, Jinhan-
dc.contributor.authorKim, Juntae-
dc.contributor.authorKim, Kiseong-
dc.contributor.authorKim, Kyung-
dc.contributor.authorKim, Sunkyu-
dc.contributor.authorKim, Yongsoo-
dc.contributor.authorKim, Yunseong-
dc.contributor.authorKirk, Paul D. W.-
dc.contributor.authorKitano, Hiroaki-
dc.contributor.authorKlambauer, Gunter-
dc.contributor.authorKnowles, David-
dc.contributor.authorKo, Melissa-
dc.contributor.authorKohn-Luque, Alvaro-
dc.contributor.authorKooistra, Albert J.-
dc.contributor.authorKuenemann, Melaine A.-
dc.contributor.authorKuiper, Martin-
dc.contributor.authorKurz, Christoph-
dc.contributor.authorKwon, Mijin-
dc.contributor.authorvan Laarhoven, Twan-
dc.contributor.authorLaegreid, Astrid-
dc.contributor.authorLederer, Simone-
dc.contributor.authorLee, Heewon-
dc.contributor.authorLee, Jeon-
dc.contributor.authorLee, Yun Woo-
dc.contributor.authorLeppaho, Eemeli-
dc.contributor.authorLewis, Richard-
dc.contributor.authorLi, Jing-
dc.contributor.authorLi, Lang-
dc.contributor.authorLiley, James-
dc.contributor.authorLim, Weng Khong-
dc.contributor.authorLin, Chieh-
dc.contributor.authorLiu, Yiyi-
dc.contributor.authorLopez, Yosvany-
dc.contributor.authorLow, Joshua-
dc.contributor.authorLysenko, Artem-
dc.contributor.authorMachado, Daniel-
dc.contributor.authorMadhukar, Neel-
dc.contributor.authorDe Maeyer, Dries-
dc.contributor.authorMalpartida, Ana Belen-
dc.contributor.authorMamitsuka, Hiroshi-
dc.contributor.authorMarabita, Francesco-
dc.contributor.authorMarchal, Kathleen-
dc.contributor.authorMarttinen, Pekka-
dc.contributor.authorMason, Daniel-
dc.contributor.authorMazaheri, Alireza-
dc.contributor.authorMehmood, Arfa-
dc.contributor.authorMehreen, Ali-
dc.contributor.authorMichaut, Magali-
dc.contributor.authorMiller, Ryan A.-
dc.contributor.authorMitsopoulos, Costas-
dc.contributor.authorModos, Dezso-
dc.contributor.authorVan Moerbeke, Marijke-
dc.contributor.authorMoo, Keagan-
dc.contributor.authorMotsinger-Reif, Alison-
dc.contributor.authorMovva, Rajiv-
dc.contributor.authorMuraru, Sebastian-
dc.contributor.authorMuratov, Eugene-
dc.contributor.authorMushthofa, Mushthofa-
dc.contributor.authorNagarajan, Niranjan-
dc.contributor.authorNakken, Sigve-
dc.contributor.authorNath, Aritro-
dc.contributor.authorNeuvial, Pierre-
dc.contributor.authorNewton, Richard-
dc.contributor.authorNing, Zheng-
dc.contributor.authorDe Niz, Carlos-
dc.contributor.authorOliva, Baldo-
dc.contributor.authorOlsen, Catharina-
dc.contributor.authorPalmeri, Antonio-
dc.contributor.authorPanesar, Bhawan-
dc.contributor.authorPapadopoulos, Stavros-
dc.contributor.authorPark, Jaesub-
dc.contributor.authorPark, Seonyeong-
dc.contributor.authorPark, Sungjoon-
dc.contributor.authorPawitan, Yudi-
dc.contributor.authorPeluso, Daniele-
dc.contributor.authorPendyala, Sriram-
dc.contributor.authorPeng, Jian-
dc.contributor.authorPerfetto, Livia-
dc.contributor.authorPirro, Stefano-
dc.contributor.authorPlevritis, Sylvia-
dc.contributor.authorPoliti, Regina-
dc.contributor.authorPoon, Hoifung-
dc.contributor.authorPorta, Eduard-
dc.contributor.authorPrellner, Isak-
dc.contributor.authorPreuer, Kristina-
dc.contributor.authorAngel Pujana, Miguel-
dc.contributor.authorRamnarine, Ricardo-
dc.contributor.authorReid, John E.-
dc.contributor.authorReyal, Fabien-
dc.contributor.authorRichardson, Sylvia-
dc.contributor.authorRicketts, Camir-
dc.contributor.authorRieswijk, Linda-
dc.contributor.authorRocha, Miguel-
dc.contributor.authorRodriguez-Gonzalvez, Carmen-
dc.contributor.authorRoell, Kyle-
dc.contributor.authorRotroff, Daniel-
dc.contributor.authorde Ruiter, Julian R.-
dc.contributor.authorRukawa, Ploy-
dc.contributor.authorSadacca, Benjamin-
dc.contributor.authorSafikhani, Zhaleh-
dc.contributor.authorSafitri, Fita-
dc.contributor.authorSales-Pardo, Marta-
dc.contributor.authorSauer, Sebastian-
dc.contributor.authorSchlichting, Moritz-
dc.contributor.authorSeoane, Jose A.-
dc.contributor.authorSerra, Jordi-
dc.contributor.authorShang, Ming-Mei-
dc.contributor.authorSharma, Alok-
dc.contributor.authorSharma, Hari-
dc.contributor.authorShen, Yang-
dc.contributor.authorShiga, Motoki-
dc.contributor.authorShin, Moonshik-
dc.contributor.authorShkedy, Ziv-
dc.contributor.authorShopsowitz, Kevin-
dc.contributor.authorSinai, Sam-
dc.contributor.authorSkola, Dylan-
dc.contributor.authorSmirnov, Petr-
dc.contributor.authorSoerensen, Izel Fourie-
dc.contributor.authorSoerensen, Peter-
dc.contributor.authorSong, Je-Hoon-
dc.contributor.authorSong, Sang Ok-
dc.contributor.authorSoufan, Othman-
dc.contributor.authorSpitzmueller, Andreas-
dc.contributor.authorSteipe, Boris-
dc.contributor.authorSuphavilai, Chayaporn-
dc.contributor.authorTamayo, Sergio Pulido-
dc.contributor.authorTamborero, David-
dc.contributor.authorTang, Jing-
dc.contributor.authorTanoli, Zia-ur-Rehman-
dc.contributor.authorTarres-Deulofeu, Marc-
dc.contributor.authorTegner, Jesper-
dc.contributor.authorThommesen, Liv-
dc.contributor.authorTonekaboni, Seyed Ali Madani-
dc.contributor.authorTran, Hong-
dc.contributor.authorDe Troyer, Ewoud-
dc.contributor.authorTruong, Amy-
dc.contributor.authorTsunoda, Tatsuhiko-
dc.contributor.authorTuru, Gabor-
dc.contributor.authorTzeng, Guang-Yo-
dc.contributor.authorVerbeke, Lieven-
dc.contributor.authorVidela, Santiago-
dc.contributor.authorVis, Daniel-
dc.contributor.authorVoronkov, Andrey-
dc.contributor.authorVotis, Konstantinos-
dc.contributor.authorWang, Ashley-
dc.contributor.authorWang, Hong-Qiang Horace-
dc.contributor.authorWang, Po-Wei-
dc.contributor.authorWang, Sheng-
dc.contributor.authorWang, Wei-
dc.contributor.authorWang, Xiaochen-
dc.contributor.authorWang, Xin-
dc.contributor.authorWennerberg, Krister-
dc.contributor.authorWernisch, Lorenz-
dc.contributor.authorWessels, Lodewyk-
dc.contributor.authorvan Westen, Gerard J. P.-
dc.contributor.authorWesterman, Bart A.-
dc.contributor.authorWhite, Simon Richard-
dc.contributor.authorWillighagen, Egon-
dc.contributor.authorWurdinger, Tom-
dc.contributor.authorXie, Lei-
dc.contributor.authorXie, Shuilian-
dc.contributor.authorXu, Hua-
dc.contributor.authorYadav, Bhagwan-
dc.contributor.authorYau, Christopher-
dc.contributor.authorYeerna, Huwate-
dc.contributor.authorYin, Jia Wei-
dc.contributor.authorYu, Michael-
dc.contributor.authorYu, MinHwan-
dc.contributor.authorYun, So Jeong-
dc.contributor.authorZakharov, Alexey-
dc.contributor.authorZamichos, Alexandros-
dc.contributor.authorZanin, Massimiliano-
dc.contributor.authorZeng, Li-
dc.contributor.authorZenil, Hector-
dc.contributor.authorZhang, Frederick-
dc.contributor.authorZhang, Pengyue-
dc.contributor.authorZhang, Wei-
dc.contributor.authorZhao, Hongyu-
dc.contributor.authorZhao, Lan-
dc.contributor.authorZheng, Wenjin-
dc.contributor.authorZoufir, Azedine-
dc.contributor.authorZucknick, Manuela-
dc.date.accessioned2021-09-01T13:41:18Z-
dc.date.available2021-09-01T13:41:18Z-
dc.date.created2021-06-19-
dc.date.issued2019-06-17-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/64754-
dc.description.abstractThe effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectANDROGEN RECEPTOR-
dc.subjectBREAST-CANCER-
dc.subjectGENE-
dc.subjectCELL-
dc.subjectINHIBITION-
dc.subjectRESISTANCE-
dc.subjectPATHWAY-
dc.subjectMUTATIONS-
dc.subjectLANDSCAPE-
dc.subjectRESOURCE-
dc.titleCommunity assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen-
dc.typeArticle-
dc.contributor.affiliatedAuthorKang, Jaewoo-
dc.identifier.doi10.1038/s41467-019-09799-2-
dc.identifier.wosid000471758500010-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.10-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume10-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusANDROGEN RECEPTOR-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusCELL-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusRESISTANCE-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusLANDSCAPE-
dc.subject.keywordPlusRESOURCE-
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