Degradation of selenoprotein S and selenoprotein K through PPAR gamma-mediated ubiquitination is required for adipocyte differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jea Hwang | - |
dc.contributor.author | Jang, Jun Ki | - |
dc.contributor.author | Ko, Kwan Young | - |
dc.contributor.author | Jin, Yunjung | - |
dc.contributor.author | Ham, Minju | - |
dc.contributor.author | Kang, Hyunwoo | - |
dc.contributor.author | Kim, Ick Young | - |
dc.date.accessioned | 2021-09-01T13:57:46Z | - |
dc.date.available | 2021-09-01T13:57:46Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64838 | - |
dc.description.abstract | Adipocyte differentiation is known to be related with endoplasmic reticulum (ER) stress. We have reported that selenoprotein S (SelS) and selenoprotein K (SelK) have a function in the regulation of ER stress and ER-associated degradation. However, the association between adipocyte differentiation and the ER-resident selenoproteins, SelS and SelK, is unclear. In this study, we found that the levels of SelS and SelK were decreased during adipocyte differentiation and were inversely related to the levels of peroxisome proliferator-activated receptor gamma (PPAR gamma), a central regulator of adipogenesis. It has been recently reported that PPAR gamma has E3 ubiquitin ligase activity. Here, we report that PPAR gamma directly interacts with both SelS and SelK via its ligand-binding domain to induce ubiquitination and degradation of the selenoproteins. Lysine residues at the 150th position of SelS and the 47th and 48th positions of SelK were the target sites for ubiquitination by PPAR gamma. We also found that adipocyte differentiation was inhibited when either SelS or SelK was not degraded by PPAR gamma. Thus, these data indicate that PPAR gamma-mediated ubiquitination and degradation of SelS and SelK is required for adipocyte differentiation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject | UNFOLDED PROTEIN RESPONSE | - |
dc.subject | BINDING | - |
dc.subject | OBESITY | - |
dc.subject | FAT | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | ACTIVATION | - |
dc.subject | INHIBITION | - |
dc.subject | BIOLOGY | - |
dc.subject | PATHWAY | - |
dc.title | Degradation of selenoprotein S and selenoprotein K through PPAR gamma-mediated ubiquitination is required for adipocyte differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ick Young | - |
dc.identifier.doi | 10.1038/s41418-018-0180-x | - |
dc.identifier.scopusid | 2-s2.0-85052284156 | - |
dc.identifier.wosid | 000467734400003 | - |
dc.identifier.bibliographicCitation | CELL DEATH AND DIFFERENTIATION, v.26, no.6, pp.1007 - 1023 | - |
dc.relation.isPartOf | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.title | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.volume | 26 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1007 | - |
dc.citation.endPage | 1023 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | PATHWAY | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.