MicroRNA miR-252 targets mbt to control the developmental growth of Drosophila
DC Field | Value | Language |
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dc.contributor.author | Lim, D. -H. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Han, J. Y. | - |
dc.contributor.author | Choi, M. -S. | - |
dc.contributor.author | Hong, J. -S. | - |
dc.contributor.author | Lee, Y. S. | - |
dc.date.accessioned | 2021-09-01T14:00:28Z | - |
dc.date.available | 2021-09-01T14:00:28Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 0962-1075 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64861 | - |
dc.description.abstract | Developmental growth is an intricate process involving the coordinated regulation of the expression of various genes, and microRNAs (miRNAs) play crucial roles in diverse processes throughout animal development. The ecdysone-responsive miRNA, miR-252, is normally upregulated during the pupal and adult stages of Drosophila development. Here, we found that overexpression of miR-252 in the larval fat body decreased total tissue mass through a reduction in both cell size and cell number, causing a concomitant decrease in larval size. Furthermore, miR-252 overexpression led to a delayed larval-to-pupal transition with defective anterior spiracle eversion, as well as a decrease in adult size and mass. Conversely, adult flies lacking miR-252 showed an increase in mass compared with control flies. We found that miR-252 directly targeted mbt, encoding a p21-activated kinase, to repress its expression. Notably, co-overexpression of mbt rescued the developmental and growth defects associated with miR-252 overexpression, indicating that mbt is a biologically relevant target of miR-252. Overall, our data support a role for the ecdysone/miR-252/mbt regulatory axis in growth control during Drosophila development. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | BETA-CATENIN | - |
dc.subject | KINASE MBT | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CANCER CELLS | - |
dc.subject | PROTEIN | - |
dc.subject | PAK4 | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | PROLIFERATION | - |
dc.subject | ACTIVATION | - |
dc.subject | CYTOSKELETON | - |
dc.title | MicroRNA miR-252 targets mbt to control the developmental growth of Drosophila | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. S. | - |
dc.identifier.doi | 10.1111/imb.12562 | - |
dc.identifier.scopusid | 2-s2.0-85060223909 | - |
dc.identifier.wosid | 000468817900012 | - |
dc.identifier.bibliographicCitation | INSECT MOLECULAR BIOLOGY, v.28, no.3, pp.444 - 454 | - |
dc.relation.isPartOf | INSECT MOLECULAR BIOLOGY | - |
dc.citation.title | INSECT MOLECULAR BIOLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 444 | - |
dc.citation.endPage | 454 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Entomology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Entomology | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | KINASE MBT | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PAK4 | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | growth | - |
dc.subject.keywordAuthor | miR-252 | - |
dc.subject.keywordAuthor | mbt | - |
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