Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Gentisyl Alcohol Inhibits Proliferation and Induces Apoptosis via Mitochondrial Dysfunction and Regulation of MAPK and PI3K/AKT Pathways in Epithelial Ovarian Cancer Cells

Authors
Ham, JiyeonLim, WhasunKim, KyeongwonHeo, Young MokRyu, Seung MokLee, DonghoKim, Jae-JinSong, Gwonhwa
Issue Date
6월-2019
Publisher
MDPI
Keywords
ovarian cancer; gentisyl alcohol; mitochondrial dysfunction; calcium dysregulation
Citation
MARINE DRUGS, v.17, no.6
Indexed
SCIE
SCOPUS
Journal Title
MARINE DRUGS
Volume
17
Number
6
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/65238
DOI
10.3390/md17060331
ISSN
1660-3397
Abstract
Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as small molecules or natural products are required. Gentisyl alcohol is one of the secondary metabolites that can be obtained by purification from bacteria or fungi and is known to have antibacterial, antifungal, antiviral, and anti-cancer effects. In the present study, we verified the effect of gentisyl alcohol derived from marine Arthrinium sp. on suppressing proliferation and inducing apoptosis via DNA fragmentation in human ovarian cancers cells (ES2 and OV90 cells). We also confirmed that there was an accumulation of sub-G1 cells and a loss of mitochondrial membrane potential with calcium dysregulation in gentisyl alcohol-treated ovarian cancer cells. Moreover, gentisyl alcohol up-regulated signal transduction of MAPK and PI3K/AKT pathways. Collectively, our results demonstrated the possibility of gentisyl alcohol as a novel therapeutic agent for human ovarian cancer.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Plant Biotechnology > 1. Journal Articles
College of Life Sciences and Biotechnology > Division of Environmental Science and Ecological Engineering > 1. Journal Articles
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Jae Jin photo

Kim, Jae Jin
생명과학대학 (환경생태공학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE