Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Hoon | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Lee, Jae Yong | - |
dc.contributor.author | Kim, Jae Gyoon | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.date.accessioned | 2021-09-01T14:50:38Z | - |
dc.date.available | 2021-09-01T14:50:38Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-05-25 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65375 | - |
dc.description.abstract | We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-alpha, and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | IMMUNOREGULATORY CYTOKINES | - |
dc.subject | FLEXOR TENDON | - |
dc.subject | TENDINOPATHY | - |
dc.subject | CELLS | - |
dc.subject | CYCLO-OXYGENASE-2 | - |
dc.subject | EXPRESSION | - |
dc.title | Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Kim, Jae Gyoon | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.identifier.doi | 10.1016/j.jiec.2019.01.018 | - |
dc.identifier.scopusid | 2-s2.0-85060753867 | - |
dc.identifier.wosid | 000462419300017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.73, pp.152 - 161 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 73 | - |
dc.citation.startPage | 152 | - |
dc.citation.endPage | 161 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002466396 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | IMMUNOREGULATORY CYTOKINES | - |
dc.subject.keywordPlus | FLEXOR TENDON | - |
dc.subject.keywordPlus | TENDINOPATHY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CYCLO-OXYGENASE-2 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Achilles tendinitis | - |
dc.subject.keywordAuthor | Fibrous sheet | - |
dc.subject.keywordAuthor | Diclofenac | - |
dc.subject.keywordAuthor | Polycaprolactone | - |
dc.subject.keywordAuthor | Tendon healing | - |
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