AU-rich element-mediated mRNA decay via the butyrate response factor 1 controls cellular levels of polyadenylated replication-dependent histone mRNAs
DC Field | Value | Language |
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dc.contributor.author | Ryu, Incheol | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-01T15:00:54Z | - |
dc.date.available | 2021-09-01T15:00:54Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-05-10 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65432 | - |
dc.description.abstract | Replication-dependent histone (RDH) mRNAs have a nonpolyadenylated 3-UTR that ends in a highly conserved stem-loop structure. Nonetheless, a subset of RDH mRNAs has a poly(A) tail under physiological conditions. The biological meaning of poly(A)-containing (+) RDH mRNAs and details of their biosynthesis remain elusive. Here, using HeLa cells and Western blotting, qRT-PCR, and biotinylated RNA pulldown assays, we show that poly(A)(+) RDH mRNAs are post-transcriptionally regulated via adenylate- and uridylate-rich element-mediated mRNA decay (AMD). We observed that the rapid degradation of poly(A)(+) RDH mRNA is driven by butyrate response factor 1 (BRF1; also known as ZFP36 ring finger protein-like 1) under normal conditions. Conversely, cellular stresses such as UV C irradiation promoted BRF1 degradation, increased the association of Hu antigen R (HuR; also known as ELAV-like RNA-binding protein 1) with the 3-UTR of poly(A)(+) RDH mRNAs, and eventually stabilized the poly(A)(+) RDH mRNAs. Collectively, our results provide evidence that AMD surveils poly(A)(+) RDH mRNAs via BRF1-mediated degradation under physiological conditions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | DEGRADATION | - |
dc.subject | PROTEIN | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | TURNOVER | - |
dc.subject | CLEAVAGE | - |
dc.subject | GENE | - |
dc.title | AU-rich element-mediated mRNA decay via the butyrate response factor 1 controls cellular levels of polyadenylated replication-dependent histone mRNAs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1074/jbc.AC118.006766 | - |
dc.identifier.scopusid | 2-s2.0-85066002021 | - |
dc.identifier.wosid | 000470153300004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.294, no.19, pp.7558 - 7565 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 294 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 7558 | - |
dc.citation.endPage | 7565 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | TURNOVER | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | RNA | - |
dc.subject.keywordAuthor | RNA degradation | - |
dc.subject.keywordAuthor | RNA metabolism | - |
dc.subject.keywordAuthor | RNA turnover | - |
dc.subject.keywordAuthor | RNA-protein interaction | - |
dc.subject.keywordAuthor | ARE-mediated mRNA decay | - |
dc.subject.keywordAuthor | mRNA stability | - |
dc.subject.keywordAuthor | posttranscriptional regulation | - |
dc.subject.keywordAuthor | polyadenylation | - |
dc.subject.keywordAuthor | butyrate response factor 1 (BRF1) | - |
dc.subject.keywordAuthor | ZFP36 ring finger protein like 1 (ZFP36L1) | - |
dc.subject.keywordAuthor | histone mRNA biogenesis | - |
dc.subject.keywordAuthor | Hu antigen R (HuR) | - |
dc.subject.keywordAuthor | ELAV like RNA binding protein 1 (ELAVL1) | - |
dc.subject.keywordAuthor | replication-dependent histone mRNA | - |
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