Effectiveness of a Fractionated Therapy Scheme in Tumor Treating Fields Therapy
DC Field | Value | Language |
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dc.contributor.author | Jo, Yunhui | - |
dc.contributor.author | Sung, Jiwon | - |
dc.contributor.author | Jeong, Hyesun | - |
dc.contributor.author | Hong, Sunghoi | - |
dc.contributor.author | Jeong, Youn Kyoung | - |
dc.contributor.author | Kim, Eun Ho | - |
dc.contributor.author | Yoon, Myonggeun | - |
dc.date.accessioned | 2021-09-01T15:00:59Z | - |
dc.date.available | 2021-09-01T15:00:59Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-05-09 | - |
dc.identifier.issn | 1533-0346 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65433 | - |
dc.description.abstract | This study aimed to evaluate the biological effectiveness of cancer therapy with tumor treating fields using a fractionated treatment scheme that was originally designed for radiotherapy. Discontinuous fractional tumor treating fields of an intensity of 0.9 to 1.2 V/cm and a frequency of 150 KHz were applied to U373 cancer cells and IEC6 normal cells for 3 days, with durations of 3, 6, 12, or 24 h/d. As the treatment duration of the tumor treating fields increased from 3 to 24 h/d, the relative tumor cell (U373) number (% of control) reduced in proportion to the treatment duration. Compared to a 25% cell number reduction (75% of control) for the group of 6 h/d treatment at 1.2 V/cm, only 5% (70% of control) and 8% (67% of control) of additional reductions were observed for the group of 12 and 24 h/d treatment, respectively. This experimental result indicates that the dependence on treatment duration in tumor cell inhibition was weakened distinctly at treatment duration over 6 h/d. For normal cells (IEC6), the relative cell number corresponding to the treatment time of the tumor treating fields at 1.2 V/cm of electric field strength was not decreased much for the treatment times of 3, 6, and 12 h/d, revealing 93.3%, 90.0%, and 89.3% relative cell numbers, respectively, but it suddenly decreased to similar to 73% for the 24 h/d treatment. Our results showed that the effects of tumor treating fields on tumor cells were higher than on normal cells for treatment duration of 3 to 12 h/d, but the difference became minimal for treatment duration of 24 h/d. The fractionated scheme, using tumor treating fields, reduced the treatment time while maintaining efficacy, suggesting that this method may be clinically applicable for cancer treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | GLIOBLASTOMA | - |
dc.title | Effectiveness of a Fractionated Therapy Scheme in Tumor Treating Fields Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Sunghoi | - |
dc.contributor.affiliatedAuthor | Yoon, Myonggeun | - |
dc.identifier.doi | 10.1177/1533033819845008 | - |
dc.identifier.scopusid | 2-s2.0-85065880841 | - |
dc.identifier.wosid | 000471354400003 | - |
dc.identifier.bibliographicCitation | TECHNOLOGY IN CANCER RESEARCH & TREATMENT, v.18 | - |
dc.relation.isPartOf | TECHNOLOGY IN CANCER RESEARCH & TREATMENT | - |
dc.citation.title | TECHNOLOGY IN CANCER RESEARCH & TREATMENT | - |
dc.citation.volume | 18 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | GLIOBLASTOMA | - |
dc.subject.keywordAuthor | tumor treating fields | - |
dc.subject.keywordAuthor | fractionated scheme | - |
dc.subject.keywordAuthor | radiotherapy | - |
dc.subject.keywordAuthor | glioblastoma | - |
dc.subject.keywordAuthor | head and neck cancer | - |
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