Ginsenoside Rd Inhibits the Metastasis of Colorectal Cancer via Epidermal Growth Factor Receptor Signaling Axis
DC Field | Value | Language |
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dc.contributor.author | Lan Thi Hanh Phi | - |
dc.contributor.author | Sari, Ita Novita | - |
dc.contributor.author | Wijaya, Yoseph Toni | - |
dc.contributor.author | Kim, Kwang Seock | - |
dc.contributor.author | Park, Kichul | - |
dc.contributor.author | Cho, Art E. | - |
dc.contributor.author | Kwon, Hyog Young | - |
dc.date.accessioned | 2021-09-01T15:40:09Z | - |
dc.date.available | 2021-09-01T15:40:09Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 1521-6543 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65826 | - |
dc.description.abstract | Ginsenoside Rd is a saponin from ginseng and has been reported to have various biological activities. However, the effect of ginsenoside Rd on the metastasis of colorectal cancer (CRC) remains unknown. Here, we found that ginsenoside Rd decreased the colony-forming ability, migration, invasion, and wound-healing abilities of CRC cells, although it did not affect cell proliferation. In addition, using an inverse-docking assay, we found that ginsenoside Rd bound to epidermal growth factor receptor (EGFR) with a high binding affinity, inducing the downregulation of stemness- and epithelial-mesenchymal transition-related genes; these were partially rescued by either exogenous EGF treatment or ectopic expression of SOX2. Furthermore, ginsenoside Rd significantly decreased the number and size of tumor metastasis nodules in the livers, lungs, and kidneys of mouse model of metastasis. (c) 2018 IUBMB Life, 71(5):601-610, 2019 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ANTICANCER ACTIVITY | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | EGFR EXPRESSION | - |
dc.subject | LUNG-CANCER | - |
dc.subject | CHALLENGES | - |
dc.subject | TARGETS | - |
dc.subject | SNAIL | - |
dc.subject | SOX2 | - |
dc.subject | RG3 | - |
dc.subject | EMT | - |
dc.title | Ginsenoside Rd Inhibits the Metastasis of Colorectal Cancer via Epidermal Growth Factor Receptor Signaling Axis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Art E. | - |
dc.identifier.doi | 10.1002/iub.1984 | - |
dc.identifier.scopusid | 2-s2.0-85058941518 | - |
dc.identifier.wosid | 000463142100007 | - |
dc.identifier.bibliographicCitation | IUBMB LIFE, v.71, no.5, pp.601 - 610 | - |
dc.relation.isPartOf | IUBMB LIFE | - |
dc.citation.title | IUBMB LIFE | - |
dc.citation.volume | 71 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 601 | - |
dc.citation.endPage | 610 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ANTICANCER ACTIVITY | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | EGFR EXPRESSION | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | CHALLENGES | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | SNAIL | - |
dc.subject.keywordPlus | SOX2 | - |
dc.subject.keywordPlus | RG3 | - |
dc.subject.keywordPlus | EMT | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | ginsenoside Rd | - |
dc.subject.keywordAuthor | CSCs | - |
dc.subject.keywordAuthor | EMT | - |
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