Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Phil Jun | - |
dc.contributor.author | Zheng, Jie | - |
dc.contributor.author | Lee, Gilju | - |
dc.contributor.author | Son, Daryeon | - |
dc.contributor.author | Kim, In Yong | - |
dc.contributor.author | Song, Gwonhwa | - |
dc.contributor.author | Park, Gyuman | - |
dc.contributor.author | You, Seungkwon | - |
dc.date.accessioned | 2021-09-01T15:44:30Z | - |
dc.date.available | 2021-09-01T15:44:30Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 1096-7176 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65858 | - |
dc.description.abstract | Reprogramming of 'adult' differentiated somatic cells to 'embryonic' pluripotent stem cells accompanied by increased rate of glycolysis. Conversely, glycolysis triggers accumulation of advanced glycation end products (AGEs), a potential causative factor in aging, by promoting methylglyoxal production. Therefore, it is reasonable that pluripotent stem cells (PSCs) would specifically regulate glycolysis to maintain their embryonic features. In this study, we focused on glycine decarboxylase (GLDC), a key enzyme in the glycine cleavage system that regulates glycolysis and methylglyoxal production in cancer. GLDC was exclusively expressed in PSCs, and inhibition of this enzyme induced alterations of metabolome and AGE accumulation, thereby suppressing the embryonic pluripotent state. Surprisingly, the level of accumulated AGEs in somatic cells gradually decreased during reprogramming, ultimately disappearing in iPSCs. In addition, ectopic expression of GLDC or treatment with the AGE inhibitor LR-90 promoted reprogramming. Together, these findings suggest that GLDC-mediated regulation of glycolysis and controlling AGE accumulation is related to maintenance and induction of pluripotency. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | STEM-CELLS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | FIBROBLASTS | - |
dc.subject | HYPOXIA | - |
dc.subject | SUPPORT | - |
dc.subject | CANCER | - |
dc.subject | SWITCH | - |
dc.subject | OCT4 | - |
dc.title | Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Phil Jun | - |
dc.contributor.affiliatedAuthor | Kim, In Yong | - |
dc.contributor.affiliatedAuthor | Song, Gwonhwa | - |
dc.contributor.affiliatedAuthor | You, Seungkwon | - |
dc.identifier.doi | 10.1016/j.ymben.2019.02.003 | - |
dc.identifier.scopusid | 2-s2.0-85061673231 | - |
dc.identifier.wosid | 000459953300004 | - |
dc.identifier.bibliographicCitation | METABOLIC ENGINEERING, v.53, pp.35 - 47 | - |
dc.relation.isPartOf | METABOLIC ENGINEERING | - |
dc.citation.title | METABOLIC ENGINEERING | - |
dc.citation.volume | 53 | - |
dc.citation.startPage | 35 | - |
dc.citation.endPage | 47 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | SUPPORT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SWITCH | - |
dc.subject.keywordPlus | OCT4 | - |
dc.subject.keywordAuthor | Glycine decarboxylase (GLDC) | - |
dc.subject.keywordAuthor | Pluripotent stem cell | - |
dc.subject.keywordAuthor | Glycolysis | - |
dc.subject.keywordAuthor | Methylglyoxal | - |
dc.subject.keywordAuthor | Advanced glycation end product (AGE) | - |
dc.subject.keywordAuthor | Reprogramming | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.