Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sung Chul | - |
dc.contributor.author | Jeen, Yoon Tae | - |
dc.date.accessioned | 2021-09-01T15:51:11Z | - |
dc.date.available | 2021-09-01T15:51:11Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65914 | - |
dc.description.abstract | The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies have identified more than 240 genetic variants related to IBD. These genetic variants are involved in innate and adaptive immunity, autophagy, defective bacterial handing, interleukin-23 and 10 signaling, and so on. According to several epidemiological and clinical studies, the phenotypes and clinical course of IBD differ between Asians and Europeans. Although the risk loci for IBD typically overlap between Asians and Westerners, genetic heterogeneity has been detected in many loci/genes, such as NOD2/CARD15, TNFSF15 and human leukocyte antigen, contributing to the risk of IBD. Thus, although common pathways exist between Westerners and Asians in the development of IBD, their significance may differ for individual pathways. Although genetic studies are not universally applicable in the clinical field, they may be useful for diagnosing and categorizing IBD, predicting therapeutic responses and toxicity to drugs, and assessing prognosis by risk modeling, thereby enabling precision medicine for individual patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | ADDITIONAL SUSCEPTIBILITY LOCI | - |
dc.subject | CROHNS-DISEASE | - |
dc.subject | ULCERATIVE-COLITIS | - |
dc.subject | CONFERS SUSCEPTIBILITY | - |
dc.subject | IMMUNOCHIP ANALYSIS | - |
dc.subject | SEQUENCE VARIANTS | - |
dc.subject | CHINESE PATIENTS | - |
dc.subject | CLINICAL-COURSE | - |
dc.subject | RISK LOCI | - |
dc.title | Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeen, Yoon Tae | - |
dc.identifier.doi | 10.3390/cells8050404 | - |
dc.identifier.wosid | 000470994400024 | - |
dc.identifier.bibliographicCitation | CELLS, v.8, no.5 | - |
dc.relation.isPartOf | CELLS | - |
dc.citation.title | CELLS | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | ADDITIONAL SUSCEPTIBILITY LOCI | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
dc.subject.keywordPlus | CONFERS SUSCEPTIBILITY | - |
dc.subject.keywordPlus | IMMUNOCHIP ANALYSIS | - |
dc.subject.keywordPlus | SEQUENCE VARIANTS | - |
dc.subject.keywordPlus | CHINESE PATIENTS | - |
dc.subject.keywordPlus | CLINICAL-COURSE | - |
dc.subject.keywordPlus | RISK LOCI | - |
dc.subject.keywordAuthor | genetics | - |
dc.subject.keywordAuthor | inflammatory bowel disease | - |
dc.subject.keywordAuthor | Crohn&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | ulcerative colitis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.