Effects of Granulocyte-Macrophage Colony-Stimulating Factor on Neuronal Senescence in Ultraviolet Irradiated Skin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Kyung-Chul | - |
dc.contributor.author | Lee, Hyun-Su | - |
dc.contributor.author | Son, Seung-Tae | - |
dc.contributor.author | Lee, Jae-Sun | - |
dc.contributor.author | Dhong, Eun-Sang | - |
dc.contributor.author | Jeong, Seong-Ho | - |
dc.contributor.author | Han, Seung-Kyu | - |
dc.date.accessioned | 2021-09-01T15:51:21Z | - |
dc.date.available | 2021-09-01T15:51:21Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 1049-2275 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65916 | - |
dc.description.abstract | Ultraviolet (UV) irradiation affects neuronal structures of the skin and accelerates skin aging. Cytokine cascades in keratinocytes after UV irradiation may result in a paracrine inhibitory effect on nerve cells. The purpose of the present study was to determine the direct effect of cytokines induced by UV radiation on nerve cells in terms of neuronal senescence. Our group performed a preliminary study to determine cytokines induced in UV-irradiated keratinocytes. Among 40 cytokines studied, granulocyte-macrophage colony-stimulating factor (GM-CSF) was increased 4-fold in inflammation antibody array. The GM-CSF was added to cultured human neuroblastoma cells. To evaluate the effect of cellular senescence, the authors performed real-time polymerase chain reaction (RT-PCR), western blot, immunocytochemical, and phase-contrast microscopic evaluations. Expression levels of matrix metallopeptidase-9 (MMP-9), nuclear factor kappa-light-chainenhancer of activated B cells 1 (NF-kB1), inducible nitric oxide synthase (iNOS), and interleukin b1 (IL-b1) were assessed by RTPCR. Expression levels of AAP and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) related to formation of betaamyloid were evaluated by western blot analysis. Expression levels of MMP-9, NF-kB1, iNOS, and IL-b1 after treatment with GMCSF were significantly higher than those in the control group. Enhanced expression of AAP and BACE1 was also observed in the treatment group. Thus, GM-CSF might have a provocative effect on nerve cells in terms of neuronal senescence. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | NERVE | - |
dc.subject | KERATINOCYTES | - |
dc.subject | DERMATITIS | - |
dc.subject | SYSTEM | - |
dc.subject | CELLS | - |
dc.title | Effects of Granulocyte-Macrophage Colony-Stimulating Factor on Neuronal Senescence in Ultraviolet Irradiated Skin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Dhong, Eun-Sang | - |
dc.contributor.affiliatedAuthor | Han, Seung-Kyu | - |
dc.identifier.doi | 10.1097/SCS.0000000000005183 | - |
dc.identifier.scopusid | 2-s2.0-85065483622 | - |
dc.identifier.wosid | 000467724100113 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CRANIOFACIAL SURGERY, v.30, no.3, pp.930 - 935 | - |
dc.relation.isPartOf | JOURNAL OF CRANIOFACIAL SURGERY | - |
dc.citation.title | JOURNAL OF CRANIOFACIAL SURGERY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 930 | - |
dc.citation.endPage | 935 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | NERVE | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | DERMATITIS | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | granulocyte-macrophage colony-stimulating factor | - |
dc.subject.keywordAuthor | nerve cell | - |
dc.subject.keywordAuthor | ultraviolet radiation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.