Visual detection of odorant geraniol enabled by integration of a human olfactory receptor into polydiacetylene/lipid nano-assembly
DC Field | Value | Language |
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dc.contributor.author | Kim, Taegon | - |
dc.contributor.author | Moon, Dongseok | - |
dc.contributor.author | Park, Jin Hyuk | - |
dc.contributor.author | Yang, Heehong | - |
dc.contributor.author | Cho, Seongyeon | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Ahn, Dong June | - |
dc.date.accessioned | 2021-09-01T15:58:43Z | - |
dc.date.available | 2021-09-01T15:58:43Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-04-28 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65961 | - |
dc.description.abstract | A new polydiacetylene lipid/human olfactory receptor nano-assembly was fabricated for the visual detection of an odorant for the first time. The assembly consisted of phospholipid-mixed polydiacetylenes (PDAs) and human olfactory receptors (hORs) in detergent micelles. To overcome the limitations of bioelectronic noses, hOR-embedded chromatic complexes (PDA/hORs) were developed, introducing PDAs that showed color and fluorescence transitions against various stimuli. The chromatic nanocomplexes reacted with target molecules, showing a fluorescence intensity increase in a dose-dependent manner and target selectivity among various odorants. As a result, a color transition of the assembly from blue to purple occurred, allowing the visual detection of the odorant geraniol. Through circular dichroism (CD) spectroscopy and a tryptophan fluorescence quenching method, the structural and functional properties of the hORs embedded in the complexes were confirmed. Based on this first work, future array devices, integrating multiple nano-assemblies, can be substantiated and utilized in environmental assessment and analysis of food quality. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | BIOELECTRONIC NOSE | - |
dc.subject | RATIONAL DESIGN | - |
dc.subject | MEMBRANE | - |
dc.subject | FILMS | - |
dc.subject | SUPRAMOLECULES | - |
dc.subject | RECONSTITUTION | - |
dc.subject | TRYPTOPHAN | - |
dc.subject | SYSTEM | - |
dc.subject | COLOR | - |
dc.subject | ASSAY | - |
dc.title | Visual detection of odorant geraniol enabled by integration of a human olfactory receptor into polydiacetylene/lipid nano-assembly | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Dong June | - |
dc.identifier.doi | 10.1039/c9nr00249a | - |
dc.identifier.scopusid | 2-s2.0-85065110059 | - |
dc.identifier.wosid | 000467776400005 | - |
dc.identifier.bibliographicCitation | NANOSCALE, v.11, no.16, pp.7582 - 7587 | - |
dc.relation.isPartOf | NANOSCALE | - |
dc.citation.title | NANOSCALE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 7582 | - |
dc.citation.endPage | 7587 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | BIOELECTRONIC NOSE | - |
dc.subject.keywordPlus | RATIONAL DESIGN | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | FILMS | - |
dc.subject.keywordPlus | SUPRAMOLECULES | - |
dc.subject.keywordPlus | RECONSTITUTION | - |
dc.subject.keywordPlus | TRYPTOPHAN | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | COLOR | - |
dc.subject.keywordPlus | ASSAY | - |
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