Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Seongsik | - |
dc.contributor.author | Reyes-Alcaraz, Arfaxad | - |
dc.contributor.author | Lee, Yoo-Na | - |
dc.contributor.author | Yong, Hyo Jeong | - |
dc.contributor.author | Choi, Jeewon | - |
dc.contributor.author | Ham, Byung-Joo | - |
dc.contributor.author | Sohn, Jong-Woo | - |
dc.contributor.author | Kim, Dong-Hoon | - |
dc.contributor.author | Son, Gi Hoon | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Kwon, Soon-Gu | - |
dc.contributor.author | Kim, Dong Sik | - |
dc.contributor.author | Kim, Bong Chul | - |
dc.contributor.author | Hwang, Jong-Ik | - |
dc.contributor.author | Seong, Jae Young | - |
dc.date.accessioned | 2021-09-01T16:02:40Z | - |
dc.date.available | 2021-09-01T16:02:40Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-04-18 | - |
dc.identifier.issn | 1662-4548 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65989 | - |
dc.description.abstract | Despite the established comorbidity between mood disorders and abnormal eating behaviors, the underlying molecular mechanism and therapeutics remain to be resolved. Here, we show that a spexin-based galanin receptor type 2 agonist (SG2A) simultaneously normalized mood behaviors and body weight in corticosterone pellet-implanted (CORTI) mice, which are underweight and exhibit signs of anhedonia, increased anxiety, and depression. Administration of SG2A into the lateral ventricle produced antidepressive and anxiolytic effects in CORTI mice. Additionally, SG2A led to a recovery of body weight in CORTI mice while it induced significant weight loss in normal mice. In Pavlovian fear-conditioned mice, SG2A decreased contextual and auditory fear memory consolidation but accelerated the extinction of acquired fear memory without altering innate fear and recognition memory. The main action sites of SG2A in the brain may include serotonergic neurons in the dorsal raphe nucleus for mood control, and proopiomelanocortin/corticotropin-releasing hormone neurons in the hypothalamus for appetite and body weight control. Furthermore, intranasal administration of SG2A exerted the same anxiolytic and antidepressant-like effects and decreased food intake and body weight in a dose-dependent manner. Altogether, these results indicate that SG2A holds promise as a clinical treatment for patients with comorbid mood disorders and abnormal appetite/body weight. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | POSTTRAUMATIC-STRESS-DISORDER | - |
dc.subject | DORSAL RAPHE | - |
dc.subject | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject | SEROTONIN | - |
dc.subject | DEPRESSION | - |
dc.subject | PEPTIDE | - |
dc.subject | OBESITY | - |
dc.subject | RAT | - |
dc.subject | PREVALENCE | - |
dc.subject | FLUOXETINE | - |
dc.title | Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ham, Byung-Joo | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Hoon | - |
dc.contributor.affiliatedAuthor | Son, Gi Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.contributor.affiliatedAuthor | Hwang, Jong-Ik | - |
dc.contributor.affiliatedAuthor | Seong, Jae Young | - |
dc.identifier.doi | 10.3389/fnins.2019.00391 | - |
dc.identifier.scopusid | 2-s2.0-85068361240 | - |
dc.identifier.wosid | 000465078900001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROSCIENCE, v.13 | - |
dc.relation.isPartOf | FRONTIERS IN NEUROSCIENCE | - |
dc.citation.title | FRONTIERS IN NEUROSCIENCE | - |
dc.citation.volume | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | POSTTRAUMATIC-STRESS-DISORDER | - |
dc.subject.keywordPlus | DORSAL RAPHE | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | FLUOXETINE | - |
dc.subject.keywordAuthor | galanin receptor 2 agonist | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | post-traumatic stress disorder | - |
dc.subject.keywordAuthor | body weight | - |
dc.subject.keywordAuthor | appetite | - |
dc.subject.keywordAuthor | intranasal administration | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.