Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Heemin | - |
dc.contributor.author | Yang, Boguang | - |
dc.contributor.author | Zhang, Kunyu | - |
dc.contributor.author | Pan, Qi | - |
dc.contributor.author | Yuan, Weihao | - |
dc.contributor.author | Li, Gang | - |
dc.contributor.author | Bian, Liming | - |
dc.date.accessioned | 2021-09-01T16:08:26Z | - |
dc.date.available | 2021-09-01T16:08:26Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-04-12 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/66017 | - |
dc.description.abstract | Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP coordination, thus producing (Mg2+-BP)-Au dimer (MgBNP). Ethylenediaminetetraacetic acid-based Mg2+ chelation facilitates the dissolution of Mg2+-BP NP, thus enabling the reversion of the MgBNP to the BNP. This convertible nanoassembly incorporating cell-adhesive Mg2+ moieties directs reversible attachment and detachment of macrophages by BP and EDTA, without physical scraping or trypsin that could damage cells. The swift formation of RGD ligand-and Mg2+-bifunctional RGD-Mg2+-BP NP that yields (RGD-Mg2+-BP)-Au dimer (RGDBNP) further stimulates the adhesion and pro-regenerative M2-type polarization of macrophages, both in vitro and in vivo, including rho-associated protein kinase. This swift and non-toxic dimer formation can include diverse bio-functional moieties to regulate host responses to implants. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CELL-ADHESION | - |
dc.subject | POLARIZATION | - |
dc.subject | MODULATION | - |
dc.subject | BISPHOSPHONATES | - |
dc.subject | INFLAMMATION | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISMS | - |
dc.subject | PHENOTYPE | - |
dc.subject | MONOCYTES | - |
dc.title | Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.identifier.doi | 10.1038/s41467-019-09733-6 | - |
dc.identifier.scopusid | 2-s2.0-85064253041 | - |
dc.identifier.wosid | 000464338100007 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.10 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | BISPHOSPHONATES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | MONOCYTES | - |
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