NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, Szu-Ting | - |
dc.contributor.author | Chen, Liang | - |
dc.contributor.author | Lin, Diego Shih-Chieh | - |
dc.contributor.author | Chen, Sei-Yi | - |
dc.contributor.author | Tsao, Yen-Po | - |
dc.contributor.author | Guo, Haitao | - |
dc.contributor.author | Li, Fei-Ju | - |
dc.contributor.author | Tseng, Wei-Ting | - |
dc.contributor.author | Tam, Jason W. | - |
dc.contributor.author | Chao, Chih-Wei | - |
dc.contributor.author | Brickey, W. June | - |
dc.contributor.author | Dzhagalov, Ivan | - |
dc.contributor.author | Song, Moon-Jung | - |
dc.contributor.author | Kang, Hye-Ri | - |
dc.contributor.author | Jung, Jae U. | - |
dc.contributor.author | Ting, Jenny P. -Y. | - |
dc.date.accessioned | 2021-09-01T16:11:07Z | - |
dc.date.available | 2021-09-01T16:11:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-04-10 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/66029 | - |
dc.description.abstract | Establishing the balance between positive and negative innate immune mechanisms is crucial for maintaining homeostasis. Here we uncover the regulatory crosstalk between two previously unlinked innate immune receptor families: RIG-I, an anti-viral cytosolic receptor activated type I interferon production, and NLR (nucleotide-binding domain, leucine repeat domain-containing protein). We show that NLRP12 dampens RIG-I-mediated immune signaling against RNA viruses by controlling RIG-I's association with its adaptor MAVS. The nucleotide-binding domain of NLRP12 interacts with the ubiquitin ligase TRIM25 to prevent TRIM25-mediated, Lys63-linked ubiquitination and activation of RIG-I. NLRP12 also enhances RNF125-mediated, Lys48-linked degradative ubiquitination of RIG-I. Vesicular stomatitis virus (VSV) infection downregulates NLRP12 expression to allow RIG-I activation. Myeloid-cell-specific Nlrp12-deficient mice display a heightened interferon and TNF response and are more resistant to VSV infection. These results indicate that NLRP12 functions as a checkpoint for anti-viral RIG-I activation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ATTENUATES COLON INFLAMMATION | - |
dc.subject | UBIQUITIN LIGASE | - |
dc.subject | NEGATIVE REGULATION | - |
dc.subject | CELL-MIGRATION | - |
dc.subject | CUTTING EDGE | - |
dc.subject | HOST-DEFENSE | - |
dc.subject | NLRX1 | - |
dc.subject | INDUCTION | - |
dc.subject | INFECTION | - |
dc.title | NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Moon-Jung | - |
dc.identifier.doi | 10.1016/j.chom.2019.02.013 | - |
dc.identifier.scopusid | 2-s2.0-85063714113 | - |
dc.identifier.wosid | 000464177000016 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, v.25, no.4, pp.602 - + | - |
dc.relation.isPartOf | CELL HOST & MICROBE | - |
dc.citation.title | CELL HOST & MICROBE | - |
dc.citation.volume | 25 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 602 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ATTENUATES COLON INFLAMMATION | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | NEGATIVE REGULATION | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | NLRX1 | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | INFECTION | - |
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