Potential of Allogeneic Adipose-Derived Stem Cell-Hydrogel Complex for Treating Diabetic Foot Ulcers
DC Field | Value | Language |
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dc.contributor.author | Moon, Kyung-Chul | - |
dc.contributor.author | Suh, Hyun-Suk | - |
dc.contributor.author | Kim, Ki-Bum | - |
dc.contributor.author | Han, Seung-Kyu | - |
dc.contributor.author | Young, Ki-Won | - |
dc.contributor.author | Lee, Jin-Woo | - |
dc.contributor.author | Kim, Mi-Hyung | - |
dc.date.accessioned | 2021-09-01T16:21:37Z | - |
dc.date.available | 2021-09-01T16:21:37Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-04-01 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/66076 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) may hold great promise for treating diabetic wounds. However, it is difficult for a clinician to use MSCs because they have not been commercialized. Meanwhile, a new commercial drug that contains adipose-derived stem cells (ASCs) has been developed. The purpose of this study was to examine the potential of allogeneic ASC sheets for treating diabetic foot ulcers. Fifty-nine patients with diabetic foot ulcers were randomized to either the ASC treatment group (n = 30) or a control group treated with polyurethane film (n = 29). Either an allogeneic ASC sheet or polyurethane film was applied on diabetic wounds weekly. These wounds were evaluated for a maximum of 12 weeks. Complete wound closure was achieved for 73% in the treatment group and 47% in the control group at week 8. Complete wound closure was achieved for 82% in the treatment group and 53% in the control group at week 12. The Kaplan-Meier median times to complete closure were 28.5 and 63.0 days for the treatment group and the control group, respectively. There were no serious adverse events related to allogeneic ASC treatment. Thus, allogeneic ASCs might be effective and safe to treat diabetic foot ulcers. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.subject | MARROW STROMAL CELLS | - |
dc.subject | FRESH FIBROBLAST ALLOGRAFTS | - |
dc.subject | HUMAN SKIN EQUIVALENT | - |
dc.subject | DERMAL FIBROBLASTS | - |
dc.subject | MULTICENTER | - |
dc.subject | EFFICACY | - |
dc.subject | SAFETY | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | MODEL | - |
dc.title | Potential of Allogeneic Adipose-Derived Stem Cell-Hydrogel Complex for Treating Diabetic Foot Ulcers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Seung-Kyu | - |
dc.identifier.doi | 10.2337/db18-0699 | - |
dc.identifier.scopusid | 2-s2.0-85063638847 | - |
dc.identifier.wosid | 000462053100015 | - |
dc.identifier.bibliographicCitation | DIABETES, v.68, no.4, pp.837 - 846 | - |
dc.relation.isPartOf | DIABETES | - |
dc.citation.title | DIABETES | - |
dc.citation.volume | 68 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 837 | - |
dc.citation.endPage | 846 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | FRESH FIBROBLAST ALLOGRAFTS | - |
dc.subject.keywordPlus | HUMAN SKIN EQUIVALENT | - |
dc.subject.keywordPlus | DERMAL FIBROBLASTS | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | MODEL | - |
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