Actual compliance to adjuvant chemotherapy in gastric cancer
- Authors
- Kim, Dong-Wook; Kwon, Oh Kyoung; Yoo, Moon-Won; Ryu, Seung-Wan; Oh, Sung Jin; Hur, Hoon; Hwang, Sun-Hwi; Lee, Junhyun; Jin, Sung-Ho; Lee, Sang Eok; Kim, Jong-Han; Kim, Jin-Jo; Jeong, In Ho; Jee, Ye Seob
- Issue Date
- 4월-2019
- Publisher
- KOREAN SURGICAL SOCIETY
- Keywords
- Compliance; Adjuvant chemotherapy; Advanced gastric cancer
- Citation
- ANNALS OF SURGICAL TREATMENT AND RESEARCH, v.96, no.4, pp.185 - 190
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANNALS OF SURGICAL TREATMENT AND RESEARCH
- Volume
- 96
- Number
- 4
- Start Page
- 185
- End Page
- 190
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/66452
- DOI
- 10.4174/astr.2019.96.4.185
- ISSN
- 2288-6575
- Abstract
- Purpose: This study aims to investigate the actual compliance with chemotherapy and analyze several factors affecting the compliance in patients with gastric cancer. Methods: From February 2012 to December 2014, we collected data of patients with gastric cancer who received adjuvant chemotherapy (TS-1 monotherapy or XELOX: capecitabine/oxaliplatin) in Korea. Results: We collected data of 1,089 patients from 31 institutions. The completion rate and dose reduction rate by age (>= 60 years vs. <60 years) were 57.5% vs. 76.8% (P < 0.001) and 17.9% vs. 21.3% (P = 0.354); by body mass index (BMI) (>= 23 kg/m(2) vs. <23 kg/m(2)) were 70.2% vs. 63.2% (P = 0.019) and 19.2% vs. 19.9% (P = 0.987), respectively. The compliance by American Society of Anesthesiologists physical status (ASA PS) classification was as follows: completion rate was 74.4%, 62.8%, and 60% (P = 0.001) and the dose reduction rate was 18.4%, 20.7%, and 17.8% (P = 0.946) in ASA PS classification I, II, and III, respectively. The completion rate of TS-1 and XELOX was 65.9% vs. 70.3% (P = 0.206) and the dose reduction rate was 15.7% vs. 33.6% (P < 0.001). Furthermore, the completion rate of chemotherapy by surgical oncologists and medical oncologists was 69.5% vs. 63.2% (P = 0.028) and the dose reduction rate was 17.4% vs. 22.3% (P = 0.035), respectively. Conclusion: The compliance was lower in patients who were older than 60 years, had BMI <23 kg/m(2), and had higher ASA PS classification. Furthermore, the patients showed higher compliance when they received chemotherapy from surgical oncologists rather than from medical oncologists.
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