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Relationship between the muscle relaxation effect and body muscle mass measured using bioelectrical impedance analysis: A nonrandomized controlled trial

Authors
Choi, Yoon-JiKim, Yun HeeBae, Go EunYu, Joon HoYoon, Seung ZhooKang, Hee WonLee, Kuen SuKim, Jae-HwanLee, Yoon-Sook
Issue Date
4월-2019
Publisher
SAGE PUBLICATIONS LTD
Keywords
Body composition; muscle relaxation; neuromuscular blocking agents; rocuronium
Citation
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.47, no.4, pp.1521 - 1532
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume
47
Number
4
Start Page
1521
End Page
1532
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/66493
DOI
10.1177/0300060518822197
ISSN
0300-0605
Abstract
Objective The dose of neuromuscular blocking drugs is commonly based on body weight, but using muscle mass might be more effective. This study investigated the relationship between the effect of neuromuscular blocking drugs and muscle mass measured using bioelectrical impedance analysis. Methods Patients who were scheduled for elective surgery using a muscle relaxant were screened for inclusion in this study. Under intravenous anaesthesia, 12 mg or 9 mg of rocuronium was administered to males and females, respectively; and the maximal relaxation effect of T1 was measured using a TOF-Watch-SX (R) acceleromyograph. Results This study enrolled 40 patients; 20 males and 20 females. For both sexes, the maximal relaxation effect of T1 did not correlate with the body weight-based dose of neuromuscular blocking drugs (males, r(2) = 0.12; females, r(2) = 0.26). Instead, it correlated with the dose based on bioelectrical impedance analysis-measured muscle mass when injected with the same dose of rocuronium (males, r(2) = 0.78, female, r(2) = 0.82). Conclusions This study showed that the muscle relaxation effect of rocuronium was correlated with muscle mass and did not correlate with body weight when using the same dose. Therefore, a muscle mass-based dose of neuromuscular blocking drugs is recommended.
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