In Vivo Imaging of Endogenously Produced HClO in Zebrafish and Mice Using a Bright, Photostable Ratiometric Fluorescent Probe
DC Field | Value | Language |
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dc.contributor.author | Duan, Chong | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Verwilst, Peter | - |
dc.contributor.author | Xu, Junchao | - |
dc.contributor.author | Kim, Hyeong Seok | - |
dc.contributor.author | Zeng, Lintao | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-01T17:16:34Z | - |
dc.date.available | 2021-09-01T17:16:34Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-03-19 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/66637 | - |
dc.description.abstract | A high brightness red fluorescent probe (S-BODIPY) has been developed for the sensitive and specific imaging of HClO/ClO- in vitro and in vivo. This probe exhibits some distinctive features such as excellent resistance to photobleaching, a high fluorescence brightness, high selectivity, as well as a good biocompatibility. Upon oxidation of the thioether group into sulfoxide, the probe showed a noticeable ratiometric fluorescence response toward ClO- with fast response (within 30 s) and a low detection limit (59 nM). The probe demonstrated the successful imaging of exogenous and endogenous HClO/ClO- in living HeLa cells, zebrafish, and mice with high signal-to-noise ratios. S-BODIPY allows for the real-time monitoring the level of ClO- in living cells by ratiometric fluorescence imaging, opening up exciting prospects to brightness and good photostability for in vivo imaging. develop red and even near-infrared BODIPYs with high | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | HYPOCHLOROUS ACID | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | LIVING CELLS | - |
dc.subject | MYELOPEROXIDASE | - |
dc.subject | GENERATION | - |
dc.subject | INFECTION | - |
dc.subject | NANOPROBE | - |
dc.subject | TOXICITY | - |
dc.subject | BASAL | - |
dc.subject | HOCL | - |
dc.title | In Vivo Imaging of Endogenously Produced HClO in Zebrafish and Mice Using a Bright, Photostable Ratiometric Fluorescent Probe | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1021/acs.analchem.9b00224 | - |
dc.identifier.scopusid | 2-s2.0-85062520370 | - |
dc.identifier.wosid | 000462098300056 | - |
dc.identifier.bibliographicCitation | ANALYTICAL CHEMISTRY, v.91, no.6, pp.4172 - 4178 | - |
dc.relation.isPartOf | ANALYTICAL CHEMISTRY | - |
dc.citation.title | ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 91 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 4172 | - |
dc.citation.endPage | 4178 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | HYPOCHLOROUS ACID | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | MYELOPEROXIDASE | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | NANOPROBE | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | BASAL | - |
dc.subject.keywordPlus | HOCL | - |
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