A Systems Vaccinology Approach Reveals the Mechanisms of Immunogenic Responses to Hantavax Vaccination in Humans
DC Field | Value | Language |
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dc.contributor.author | Khan, Adnan | - |
dc.contributor.author | Shin, Ok Sarah | - |
dc.contributor.author | Na, Jinhyuk | - |
dc.contributor.author | Kim, Jae Kwan | - |
dc.contributor.author | Seong, Rak-Kyun | - |
dc.contributor.author | Park, Man-Seong | - |
dc.contributor.author | Noh, Jiyun | - |
dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Cheong, Hee Jin | - |
dc.contributor.author | Park, Youngia Hwang | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.date.accessioned | 2021-09-01T17:17:30Z | - |
dc.date.available | 2021-09-01T17:17:30Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-03-18 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/66645 | - |
dc.description.abstract | Hantavax is an inactivated vaccine for hemorrhagic fever with renal syndrome (HFRS). The immunogenic responses have not been elucidated yet. Here we conducted a cohort study in which 20 healthy subjects were administered four doses of Hantavax during 13-months period. Pre- and post-vaccinated peripheral blood mononuclear cells (PBMCs) and sera were analysed by transcriptomic and metabolomic profilings, respectively. Based on neutralizing antibody titers, subjects were subsequently classified into three groups; non responders (NRs), low responders (LRs) and high responders (HRs). Post vaccination differentially expressed genes (DEGs) associated with innate immunity and cytokine pathways were highly upregulated. DEG analysis revealed a significant induction of CD69 expression in the HRs. High resolution metabolomics (HRM) analysis showed that correlated to the antibody response, cholesteryl nitrolinoleate, octanoyl-carnitine, tyrosine, ubiquinone-9, and benzoate were significantly elevated in HRs, while chenodeoxycholic acid and methyl palmitate were upregulated in NRs and LRs, compared with HRs. Additionally, gene-metabolite interaction revealed upregulated gene-metabolite couplings in, folate biosynthesis, nicotinate and nicotinamide, arachidonic acid, thiamine and pyrimidine metabolism in a dose dependent manner in HR group. Collectively, our data provide new insight into the underlying mechanisms of the Hantavax-mediated immunogenicity in humans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | PARENTERAL-NUTRITION | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | ARGININE | - |
dc.subject | METABOLOMICS | - |
dc.subject | METABOLITES | - |
dc.subject | CHILDREN | - |
dc.subject | INNATE | - |
dc.subject | FEVER | - |
dc.subject | ACIDS | - |
dc.title | A Systems Vaccinology Approach Reveals the Mechanisms of Immunogenic Responses to Hantavax Vaccination in Humans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Ok Sarah | - |
dc.contributor.affiliatedAuthor | Park, Man-Seong | - |
dc.contributor.affiliatedAuthor | Noh, Jiyun | - |
dc.contributor.affiliatedAuthor | Song, Joon Young | - |
dc.contributor.affiliatedAuthor | Cheong, Hee Jin | - |
dc.contributor.affiliatedAuthor | Park, Youngia Hwang | - |
dc.contributor.affiliatedAuthor | Kim, Woo Joo | - |
dc.identifier.doi | 10.1038/s41598-019-41205-1 | - |
dc.identifier.scopusid | 2-s2.0-85063043679 | - |
dc.identifier.wosid | 000461417700002 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PARENTERAL-NUTRITION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ARGININE | - |
dc.subject.keywordPlus | METABOLOMICS | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | FEVER | - |
dc.subject.keywordPlus | ACIDS | - |
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