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A novel helper qPCR system for platinum detection via Pt-DNA coordination

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dc.contributor.authorCai, Sheng-
dc.contributor.authorYang, Dan-
dc.contributor.authorTian, Xueke-
dc.contributor.authorYe, Jiawei-
dc.contributor.authorXu, Mingcheng-
dc.contributor.authorAl-Maskri, Abdu Ahmed Abdullah-
dc.contributor.authorJung, Cheulhee-
dc.contributor.authorZeng, Su-
dc.date.accessioned2021-09-01T17:49:23Z-
dc.date.available2021-09-01T17:49:23Z-
dc.date.created2021-06-19-
dc.date.issued2019-03-07-
dc.identifier.issn0003-2670-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/66995-
dc.description.abstractA novel real-time polymerase chain reaction (qPCR) platform for the simple and robust detection of platinum is described for the first time. Compared with conventional qPCR, a helper template, which is related to the active template for performing qPCR, was introduced in our helper qPCR system. Several guanine (G) bases were introduced in the helper template to obtain a platinum-responsive on/off switch based on G-Pt-G coordination. Because of the helper template, a slight change in platinum concentration would significantly change the signal in the qPCR. This novel helper qPCR technique easily detects platinum with high sensitivity (1 ng/mL) and selectivity over other metal ions. Therefore, it will be a promising technique for the detection of platinum in biomedical and environmental samples. (c) 2018 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectELECTROCHEMICAL BIOSENSOR-
dc.subjectLIQUID-CHROMATOGRAPHY-
dc.subjectSENSITIVE DETECTION-
dc.subjectINTACT CISPLATIN-
dc.subjectBLOOD-PLASMA-
dc.subjectHUMAN SERUM-
dc.subjectICP-MS-
dc.subjectOXALIPLATIN-
dc.subjectIONS-
dc.subjectMECHANISMS-
dc.titleA novel helper qPCR system for platinum detection via Pt-DNA coordination-
dc.typeArticle-
dc.contributor.affiliatedAuthorJung, Cheulhee-
dc.identifier.doi10.1016/j.aca.2018.11.007-
dc.identifier.scopusid2-s2.0-85056818537-
dc.identifier.wosid000455933400018-
dc.identifier.bibliographicCitationANALYTICA CHIMICA ACTA, v.1050, pp.154 - 160-
dc.relation.isPartOfANALYTICA CHIMICA ACTA-
dc.citation.titleANALYTICA CHIMICA ACTA-
dc.citation.volume1050-
dc.citation.startPage154-
dc.citation.endPage160-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.subject.keywordPlusELECTROCHEMICAL BIOSENSOR-
dc.subject.keywordPlusLIQUID-CHROMATOGRAPHY-
dc.subject.keywordPlusSENSITIVE DETECTION-
dc.subject.keywordPlusINTACT CISPLATIN-
dc.subject.keywordPlusBLOOD-PLASMA-
dc.subject.keywordPlusHUMAN SERUM-
dc.subject.keywordPlusICP-MS-
dc.subject.keywordPlusOXALIPLATIN-
dc.subject.keywordPlusIONS-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordAuthorHelper qPCR platform-
dc.subject.keywordAuthorPt-DNA coordination-
dc.subject.keywordAuthorPlatinum-responsive on/off switch-
dc.subject.keywordAuthorPlatinum detection-
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