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Ursodeoxycholic acid exerts hepatoprotective effects by regulating amino acid, flavonoid, and fatty acid metabolic pathways

Authors
Kim, Da JungChung, HyewonJi, Sang ChunLee, SeungHwanYu, Kyung-SangJang, In-JinCho, Joo-Youn
Issue Date
3월-2019
Publisher
SPRINGER
Keywords
Ursodeoxycholic acid; Global metabolomics; Hepatoprotective effect; Amino acid; Flavonoid; Fatty acid
Citation
METABOLOMICS, v.15, no.3
Indexed
SCIE
SCOPUS
Journal Title
METABOLOMICS
Volume
15
Number
3
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67082
DOI
10.1007/s11306-019-1494-5
ISSN
1573-3882
Abstract
IntroductionUrsodeoxycholic acid (UDCA) is an intestinal bacterial metabolite with hepatoprotective effects. However, molecular mechanisms underlying its effects remain unclear.ObjectivesThe aim of this study was to investigate the mechanisms underlying the therapeutic effects of UDCA by using global metabolomics analyses in healthy subjects.MethodsHealthy Korean men were administered UDCA at dosage of 400, 800, or 1200mg daily for 2weeks. Serum samples were collected and used for liver function tests and to determine miR-122 expression levels. Urinary and plasma global metabolomics analyses were conducted using a liquid chromatography system coupled with quadrupole-time-of-flight mass spectrometry (LC/QTOFMS) and gas chromatography-TOFMS (GC/TOFMS). Unsupervised multivariate analysis (principal component analysis) was performed to identify discriminative markers before and after treatment.ResultsAlanine transaminase score and serum miR-122 levels decreased significantly after 2weeks of treatment. Through LC- and GC-based metabolomic profiling, we identified 40 differential metabolites in plasma and urine samples.ConclusionsRegulation of liver function scores and metabolic alternations highlight the potential hepatoprotective action of UDCA, which were primarily associated with amino acid, flavonoid, and fatty acid metabolism in healthy men.
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