Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Je Won | - |
dc.contributor.author | Yoon, Yeo Joon | - |
dc.date.accessioned | 2021-09-01T18:00:35Z | - |
dc.date.available | 2021-09-01T18:00:35Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1367-5435 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67085 | - |
dc.description.abstract | Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | MODULAR POLYKETIDE SYNTHASE | - |
dc.subject | ERYTHROMYCIN-A PRODUCTION | - |
dc.subject | IN-VITRO | - |
dc.subject | ANTIBACTERIAL ACTIVITY | - |
dc.subject | E. COLI | - |
dc.subject | DOMAIN | - |
dc.subject | STRAIN | - |
dc.subject | REGULATOR | - |
dc.subject | ANALOGS | - |
dc.subject | ANTHRACIMYCIN | - |
dc.title | Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Je Won | - |
dc.identifier.doi | 10.1007/s10295-018-2095-4 | - |
dc.identifier.scopusid | 2-s2.0-85056298131 | - |
dc.identifier.wosid | 000460642800017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.46, no.3-4, pp.445 - 458 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | 445 | - |
dc.citation.endPage | 458 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | MODULAR POLYKETIDE SYNTHASE | - |
dc.subject.keywordPlus | ERYTHROMYCIN-A PRODUCTION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | E. COLI | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | STRAIN | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | ANTHRACIMYCIN | - |
dc.subject.keywordAuthor | 14-Membered macrolide | - |
dc.subject.keywordAuthor | Polyketide synthase | - |
dc.subject.keywordAuthor | Post-polyketide synthase tailoring | - |
dc.subject.keywordAuthor | Combinatorial biosynthesis | - |
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