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The role of senescence of bone marrow cells in acute kidney injury

Authors
Lee, JunyongKo, Yoon SookLee, Hee YoungYang, JihyunOh, SewonJo, Sang-KyungCho, WonyongKim, Myung-Gyu
Issue Date
3월-2019
Publisher
KOREAN SOC NEPHROLOGY
Keywords
Acute kidney injury; Aging; Immunosenescence; Ischemia reperfusion injury
Citation
KIDNEY RESEARCH AND CLINICAL PRACTICE, v.38, no.1, pp.25 - 32
Indexed
SCOPUS
KCI
Journal Title
KIDNEY RESEARCH AND CLINICAL PRACTICE
Volume
38
Number
1
Start Page
25
End Page
32
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67122
DOI
10.23876/j.krcp.18.0114
ISSN
2211-9132
Abstract
Background: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes. This study aimed to investigate the role of senescence of bone marrow (BM)-derived cells in the development of AKI, focusing on the immune response. Methods: Female 7-week-old C57BL/6 mice were irradiated and treated with BM cells from either 48-week-old or 8-week-old male mice. lschemia-reperfusion injury (IRI) was induced, and their functional deterioration, histological tubular damage, and inflammatory responses were compared. For the in-vitro study, lipopolysaccharide (LPS)-stimulated cytokine production by BM cells from old and young mice were examined. Results: At 24 hours after IRI, there was no significant difference in the number of circulating immune cells between the mice transplanted with old or young BM cells. However, the mice with old BM cells showed less functional deterioration and histological tubular injury than those with young BM cells. Moreover, macrophage infiltration and renal cytokine interleukin (IL)-12 levels were lower in the mice with old BM cells at 24 hours post-IRI. Consistently, the in vitro study showed that LPS-induced production of cytokines interferon-y, monocyte chemoattractant protein-1, and IL-10 was attenuated in cultured old BM cells, suggesting that age-related functional changes in these cells may lead to reduced inflammation in IRI. Conclusion: Immunosenescence could affect the susceptibility and response to renal IRI. Further studies specifically addressing age-related alterations can help in the development of treatment strategies for elderly patients with AKI.
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