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Role of nuclear mechanosensitivity in determining cellular responses to forces and biomaterials

Authors
Lee, Jung-HwanKim, Dong-HweeLee, Hae-HyoungKim, Hae-Won
Issue Date
3월-2019
Publisher
ELSEVIER SCI LTD
Keywords
Mechanotransduction; External physical cues; Adhesion molecules; Nucleus; Cell engineering
Citation
BIOMATERIALS, v.197, pp.60 - 71
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
197
Start Page
60
End Page
71
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67206
DOI
10.1016/j.biomaterials.2019.01.010
ISSN
0142-9612
Abstract
Tissue engineers use biomaterials or apply forces to alter cell behaviors and cure damaged/diseased tissues. The external physical cues perceived by cells are transduced intracellularly along the mechanosensitive machineries, including subcellular adhesion molecules and cytoskeletons. The signals are further channeled to a nucleus through the physical links of nucleoskeleton and cytoskeleton or the biochemical translocation of transcription factors. Thus, the external cues are thought to affect directly or indirectly the nucleus and the genetic transcriptional process, ultimately determining cell fate. Here we communicate the importance of such mechanotransductory processes in cell and tissue engineering where external forces- or biomaterials-related physical cues essentially regulate cellular behaviors, with an emphasis on the mechanosensing and signaling along the road to a nucleus.
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