The role of nuclear factor erythroid-2-related factor 2 expression in radiocontrast-induced nephropathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Bae, So Yeon | - |
dc.contributor.author | Ahn, Shin Young | - |
dc.contributor.author | Kwon, Young Joo | - |
dc.contributor.author | Ko, Gang Jee | - |
dc.date.accessioned | 2021-09-01T18:29:12Z | - |
dc.date.available | 2021-09-01T18:29:12Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02-22 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67289 | - |
dc.description.abstract | Radiocontrast-induced nephropathy (CIN) is the third most common cause of acute renal failure. The pathophysiology of CIN is related to tubular injury caused by oxidative stress, and nuclear factor erythroid-2-related factor 2 (Nrf2) is critical in coordinating intracellular antioxidative processes. We thus investigated the role of Nrf2 in CIN. CIN was established in mice and in NRK-52E cells via iohexol administration according to the protocols of previous studies. To determine the role of Nrf2 in CIN, Nrf2 expression was reduced in vivo using Nrf2 knockout (KO) mice (B6.129 x 1-Nfe2 l2tmlYwk/J) and in vitro with siRNA treatment targeting Nrf2. Increased Nrf2 expression was observed after iohexol treatment both in vivo and in vitro. Serum creatinine at 24 h after iohexol injection was significantly higher in KO mice than in wild-type (WT) mice. Histologic examination showed that iohexol-induced tubular vacuolization and structural disruption were aggravated in Nrf2 KO mice. Significant increases in apoptosis and F4/80(+) inflammatory cell infiltration were demonstrated in KO mice compared to WT mice. In addition, the increase in reactive oxygen species after iohexol treatment was augmented by Nrf2 inhibition both in vivo and in vitro. Nrf2 may be implicated in the pathogenesis of CIN via the modulation of antioxidant, anti-apoptotic, and anti-inflammatory processes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CONTRAST-INDUCED NEPHROPATHY | - |
dc.subject | TRANSCRIPTION FACTOR NRF2 | - |
dc.subject | ACUTE KIDNEY INJURY | - |
dc.subject | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject | TYPE-2 DIABETES-MELLITUS | - |
dc.subject | N-ACETYLCYSTEINE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | BARDOXOLONE METHYL | - |
dc.subject | HEME OXYGENASE-1 | - |
dc.subject | SULFORAPHANE PROTECTS | - |
dc.title | The role of nuclear factor erythroid-2-related factor 2 expression in radiocontrast-induced nephropathy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Shin Young | - |
dc.contributor.affiliatedAuthor | Kwon, Young Joo | - |
dc.contributor.affiliatedAuthor | Ko, Gang Jee | - |
dc.identifier.doi | 10.1038/s41598-019-39534-2 | - |
dc.identifier.scopusid | 2-s2.0-85062021780 | - |
dc.identifier.wosid | 000459399400077 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CONTRAST-INDUCED NEPHROPATHY | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR NRF2 | - |
dc.subject.keywordPlus | ACUTE KIDNEY INJURY | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | N-ACETYLCYSTEINE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BARDOXOLONE METHYL | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | SULFORAPHANE PROTECTS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.