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Unraveling the Mechanobiology of the Immune System

Authors
Kim, Jeong-KiShin, Yu JungHa, Leslie JaesunKim, Deok-HoKim, Dong-Hwee
Issue Date
21-2월-2019
Publisher
WILEY
Keywords
immune cells; immune response; mechanobiology; mechanoregulation
Citation
ADVANCED HEALTHCARE MATERIALS, v.8, no.4
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED HEALTHCARE MATERIALS
Volume
8
Number
4
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67596
DOI
10.1002/adhm.201801332
ISSN
2192-2640
Abstract
Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology.
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