A pH-Responsive Glycyrrhetinic-Acid-Modified Small-Molecule Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC)
DC Field | Value | Language |
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dc.contributor.author | Singh, Hardev | - |
dc.contributor.author | Lim, Ja-Yun | - |
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Yoon, Dae Wui | - |
dc.contributor.author | Kim, Ji Hyeon | - |
dc.contributor.author | Yang, Zhigang | - |
dc.contributor.author | Qu, Junle | - |
dc.contributor.author | Kim, Jinkwan | - |
dc.contributor.author | Lee, Seung Gwan | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-01T19:04:02Z | - |
dc.date.available | 2021-09-01T19:04:02Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02-15 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67626 | - |
dc.description.abstract | We report a glycyrrhetinic-acid (GA)-decorated small-molecule conjugate for pH-triggered near-infrared (NIR) fluorescence imaging of hepatocellular carcinoma (HCC). Our in vitro studies demonstrated that the conjugate, referred to as NIR-GA, was efficiently taken up by liver cancer cell lines such as HepG2 and Huh7 through an endocytic pathway mediated by GA receptors. As suggested by co-localization studies, NIR-GA mainly localized in the lysosome, where the acidic pH results in the activation of the fluorescent dye through H+-triggered spirolactam ring opening to give strong fluorescence in the NIR region. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | INFRARED FLUORESCENT-PROBES | - |
dc.subject | ASIALOGLYCOPROTEIN RECEPTOR | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | LIVING CELLS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | PRODRUG | - |
dc.subject | BINDING | - |
dc.subject | DESIGN | - |
dc.title | A pH-Responsive Glycyrrhetinic-Acid-Modified Small-Molecule Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Seung Gwan | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1002/cbic.201800619 | - |
dc.identifier.scopusid | 2-s2.0-85060337974 | - |
dc.identifier.wosid | 000458825800023 | - |
dc.identifier.bibliographicCitation | CHEMBIOCHEM, v.20, no.4, pp.614 - 620 | - |
dc.relation.isPartOf | CHEMBIOCHEM | - |
dc.citation.title | CHEMBIOCHEM | - |
dc.citation.volume | 20 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 614 | - |
dc.citation.endPage | 620 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | INFRARED FLUORESCENT-PROBES | - |
dc.subject.keywordPlus | ASIALOGLYCOPROTEIN RECEPTOR | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PRODRUG | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordAuthor | fluorescent probes | - |
dc.subject.keywordAuthor | glycyrrhetinic acid | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | imaging agents | - |
dc.subject.keywordAuthor | natural products | - |
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