Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Davies, Alexander J. | - |
dc.contributor.author | Kim, Hyoung Woo | - |
dc.contributor.author | Gonzalez-Cano, Rafael | - |
dc.contributor.author | Choi, Jahyang | - |
dc.contributor.author | Back, Seung Keun | - |
dc.contributor.author | Roh, Seung Eon | - |
dc.contributor.author | Johnson, Errin | - |
dc.contributor.author | Gabriac, Melanie | - |
dc.contributor.author | Kim, Mi-Sun | - |
dc.contributor.author | Lee, Jaehee | - |
dc.contributor.author | Lee, Jeong Eun | - |
dc.contributor.author | Kim, Yun Sook | - |
dc.contributor.author | Bae, Yong Chul | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.contributor.author | Na, Heung Sik | - |
dc.contributor.author | Riva, Priscilla | - |
dc.contributor.author | Latremoliere, Alban | - |
dc.contributor.author | Rinaldi, Simon | - |
dc.contributor.author | Ugolini, Sophie | - |
dc.contributor.author | Costigan, Michael | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.date.accessioned | 2021-09-01T19:06:44Z | - |
dc.date.available | 2021-09-01T19:06:44Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02-07 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67648 | - |
dc.description.abstract | Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the integrity of damaged axons preserved. We show that an endogenous ligand for the natural killer (NK) cell receptor NKG2D, Retinoic Acid Early 1 (RAE1), is re-expressed in adult dorsal root ganglion neurons following peripheral nerve injury, triggering selective degeneration of injured axons. Infiltration of cytotoxic NK cells into the sciatic nerve by extravasation occurs within 3 days following crush injury. Using a combination of genetic cell ablation and cytokine-antibody complex stimulation, we show that NK cell function correlates with loss of sensation due to degeneration of injured afferents and reduced incidence of post-injury hypersensitivity. This neuro-immune mechanism of selective NK cell-mediated degeneration of damaged but intact sensory axons complements Wallerian degeneration and suggests the therapeutic potential of modulating NK cell function to resolve painful neuropathy through the clearance of partially damaged nerves. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | ROOT GANGLIA NEURONS | - |
dc.subject | SELF-DESTRUCTION | - |
dc.subject | MEDIATED LYSIS | - |
dc.subject | IMMUNE | - |
dc.subject | MODEL | - |
dc.subject | MECHANISMS | - |
dc.subject | GRANZYMES | - |
dc.subject | PERFORIN | - |
dc.subject | SUBSETS | - |
dc.subject | STIMULI | - |
dc.title | Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kyung-Mi | - |
dc.contributor.affiliatedAuthor | Na, Heung Sik | - |
dc.identifier.doi | 10.1016/j.cell.2018.12.022 | - |
dc.identifier.scopusid | 2-s2.0-85061009910 | - |
dc.identifier.wosid | 000457969200006 | - |
dc.identifier.bibliographicCitation | CELL, v.176, no.4, pp.716 - + | - |
dc.relation.isPartOf | CELL | - |
dc.citation.title | CELL | - |
dc.citation.volume | 176 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 716 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ROOT GANGLIA NEURONS | - |
dc.subject.keywordPlus | SELF-DESTRUCTION | - |
dc.subject.keywordPlus | MEDIATED LYSIS | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | GRANZYMES | - |
dc.subject.keywordPlus | PERFORIN | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | STIMULI | - |
dc.subject.keywordAuthor | autoimmunity | - |
dc.subject.keywordAuthor | dorsal root ganglia | - |
dc.subject.keywordAuthor | innate immunity | - |
dc.subject.keywordAuthor | natural cytotoxicity | - |
dc.subject.keywordAuthor | neurodegeneration | - |
dc.subject.keywordAuthor | neuroimmune | - |
dc.subject.keywordAuthor | neuropathic pain | - |
dc.subject.keywordAuthor | peripheral neuropathy | - |
dc.subject.keywordAuthor | sciatic nerve crush | - |
dc.subject.keywordAuthor | Wallerian degeneration | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.