Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

One-Pot Synthesis of a Zwitterionic Small Molecule Bearing Disulfide Moiety for Antibiofouling Macro- and Nanoscale Gold Surfaces

Authors
Yi, SeungjooLee, Won KyuPark, Ji-HoLee, Jae-SeungSeo, Ji-Hun
Issue Date
5-2월-2019
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.35, no.5, pp.1768 - 1777
Indexed
SCIE
SCOPUS
Journal Title
LANGMUIR
Volume
35
Number
5
Start Page
1768
End Page
1777
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67661
DOI
10.1021/acs.langmuir.8b01532
ISSN
0743-7463
Abstract
The goal of this study is to develop a simple one-pot method for the synthesis of a zwitterionic small molecule bearing disulfide moiety, which can effectively inhibit nonspecific protein adsorption on macroscopic and nanoscopic gold surfaces. To this end, the optimal molecular structure of a pyridine disulfide derivative was explored and a zwitterionic small molecule was successfully synthesized from the tertiary amine residue on the pyridine ring through a one pot method. The coating conditions of the synthesized zwitterionic molecules on the gold surface were optimized through contact angle measurements, and the strong interactions between the gold surface and the disulfide moiety of the zwitterion small molecule were confirmed by surface plasmon resonance (SPR) analysis and X-ray photoelectron spectroscopy. The antibiofouling properties of the coated gold surface were analyzed by fluorescence microscopic observations after contacting with FITC-labeled bovine serum albumin (BSA) and SPR sensor as contacting with BSA solution. In addition, the effect of zwitterion-coating on the salt stability of and protein adsorption on nanoscopic gold surfaces were examined through a NaCl stability test and BSA adsorption test, respectively. From the obtained results, it was confirmed that the simply synthesized zwitterionic small molecule was effective in inhibiting nonspecific protein adsorption on macroscopic and nanoscopic gold surfaces; further, it enhanced the salt stability of gold nanoparticle surfaces.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Engineering > Department of Materials Science and Engineering > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Jae Seung photo

Lee, Jae Seung
공과대학 (신소재공학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE