HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions
DC Field | Value | Language |
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dc.contributor.author | Ryu, Incheol | - |
dc.contributor.author | Park, Yeonkyoung | - |
dc.contributor.author | Seo, Jwa-Won | - |
dc.contributor.author | Park, Ok Hyun | - |
dc.contributor.author | Ha, Hongseok | - |
dc.contributor.author | Nam, Jin-Wu | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-01T19:18:26Z | - |
dc.date.available | 2021-09-01T19:18:26Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67717 | - |
dc.description.abstract | All metazoan mRNAs have a poly(A) tail at the 3 end with the exception of replication-dependent histone (RDH) mRNAs, which end in a highly conserved stem-loop (SL) structure. However, a subset of RDH mRNAs are reported to be polyadenylated under physiologic conditions. The molecular details of the biogenesis of polyadenylated RDH [poly(A)(+) RDH] mRNAs remain unknown. In this study, our genome-wide analyses reveal that puromycin treatment or UVC irradiation stabilizes poly(A)(+) RDH mRNAs, relative to canonical RDH mRNAs, which end in an SL structure. We demonstrate that the stabilization of poly(A)(+) RDH mRNAs occurs in a translation-independent manner and is regulated via human antigen R (HuR) binding to the extended 3 UTR under stress conditions. Our data suggest that HuR regulates the expression of poly(A)(+) RDH mRNAs.Ryu, I., Park, Y., Seo, J.-W., Park, O. H., Ha, H., Nam, J.-W., Kim, Y. K. HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.subject | LOOP-BINDING-PROTEIN | - |
dc.subject | ALTERNATIVE POLYADENYLATION | - |
dc.subject | STEM-LOOP | - |
dc.subject | RAPID DEGRADATION | - |
dc.subject | EXPRESSION | - |
dc.subject | GENE | - |
dc.subject | CLEAVAGE | - |
dc.subject | MECHANISM | - |
dc.subject | COMPLEX | - |
dc.subject | INTERACTS | - |
dc.title | HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ha, Hongseok | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1096/fj.201800431R | - |
dc.identifier.scopusid | 2-s2.0-85061059167 | - |
dc.identifier.wosid | 000457296600092 | - |
dc.identifier.bibliographicCitation | FASEB JOURNAL, v.33, no.2, pp.2680 - 2693 | - |
dc.relation.isPartOf | FASEB JOURNAL | - |
dc.citation.title | FASEB JOURNAL | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 2680 | - |
dc.citation.endPage | 2693 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | LOOP-BINDING-PROTEIN | - |
dc.subject.keywordPlus | ALTERNATIVE POLYADENYLATION | - |
dc.subject.keywordPlus | STEM-LOOP | - |
dc.subject.keywordPlus | RAPID DEGRADATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordAuthor | mRNA stability | - |
dc.subject.keywordAuthor | 3UTR | - |
dc.subject.keywordAuthor | polyadenylation signal | - |
dc.subject.keywordAuthor | UVC | - |
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