Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss-Side Effect
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seonhwa | - |
dc.contributor.author | Lee, Hae-June | - |
dc.contributor.author | Kang, Hyunji | - |
dc.contributor.author | Kim, Eun-Ho | - |
dc.contributor.author | Lim, Young-Cheol | - |
dc.contributor.author | Park, Hyejin | - |
dc.contributor.author | Lim, Sang Moo | - |
dc.contributor.author | Lee, Yong Jin | - |
dc.contributor.author | Kim, Jung Min | - |
dc.contributor.author | Kim, Jin Su | - |
dc.date.accessioned | 2021-09-01T19:40:30Z | - |
dc.date.available | 2021-09-01T19:40:30Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67739 | - |
dc.description.abstract | The authors identified that chemo-brain was induced after trastuzumab (TZB) therapy. In addition, atorvastatin (ATV) could rescue chemo-brain during trastuzumab (TZB) therapy. Enhanced therapeutic effect of TZB was confirmed after ATV therapy. We also investigated that there was no hair loss side effect due to ATV therapy. In an animal model, 150 mu g TZB and five serial doses of 20 mg/kg ATV were administered. F-18-fluorodeoxyglucose Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) data were acquired. Statistical parametric mapping analysis and voxel-based morphometry analysis were performed to identify differences in glucose metabolism and gray matter concentration. The enhanced therapeutic efficacy of TZB after ATV treatment was assessed using a human epidermal growth factor receptor 2-positive gastric cancer model. We found a decrease in cerebral glucose metabolism and gray matter concentration in the frontal lobe following TZB therapy (p < 0.005). After subsequent ATV administration, glucose metabolism and regional gray matter concentration were rescued (p < 0.005). Cognitive impairment due to TZB and the rescue effect of ATV were confirmed using a passive avoidance test and quantitative real-time reverse transcription PCR. Furthermore, the penetration and accumulation of TZB in tumors increased by 100% after ATV co-administration, which resulted in an enhanced anti-cancer effect. Our study collectively demonstrates that ATV co-administration with TZB rescued the TZB-induced chemo-brain and enhances the therapeutic efficacy of TZB in tumors. We also showed that there was no hair loss during ATV therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | COGNITIVE DEFICITS | - |
dc.subject | INDUCED ALOPECIA | - |
dc.subject | GASTRIC-CANCER | - |
dc.subject | STATINS | - |
dc.subject | RADIOIMMUNOTHERAPY | - |
dc.subject | CYTOKINES | - |
dc.subject | UPDATE | - |
dc.subject | IMPACT | - |
dc.subject | MODEL | - |
dc.title | Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss-Side Effect | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Min | - |
dc.identifier.doi | 10.3390/jcm8020234 | - |
dc.identifier.wosid | 000460295400107 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.2 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | COGNITIVE DEFICITS | - |
dc.subject.keywordPlus | INDUCED ALOPECIA | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | STATINS | - |
dc.subject.keywordPlus | RADIOIMMUNOTHERAPY | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | chemo-brain | - |
dc.subject.keywordAuthor | trastuzumab therapy | - |
dc.subject.keywordAuthor | atorvastatin | - |
dc.subject.keywordAuthor | anti-cancer effect | - |
dc.subject.keywordAuthor | radiomics | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.