Long-term Prognosis of Acute-on-Chronic Liver Failure Survivors
DC Field | Value | Language |
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dc.contributor.author | Yoon, Eileen L. | - |
dc.contributor.author | Kim, Tae Yeob | - |
dc.contributor.author | Lee, Chang Hyeong | - |
dc.contributor.author | Kim, Tae Hun | - |
dc.contributor.author | Cho, Hyun Chin | - |
dc.contributor.author | Lee, Sang Soo | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Kim, Hee Yeon | - |
dc.contributor.author | Kim, Chang Wook | - |
dc.contributor.author | Song, Do Seon | - |
dc.contributor.author | Yang, Jin Mo | - |
dc.contributor.author | Sinn, Dong Hyun | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Kim, Hyoung Su | - |
dc.contributor.author | Sohn, Joo Hyun | - |
dc.contributor.author | Kim, Jeong Han | - |
dc.contributor.author | Choe, Won Hyeok | - |
dc.contributor.author | Lee, Byung Seok | - |
dc.contributor.author | Kim, Moon Young | - |
dc.contributor.author | Jeong, Soung Won | - |
dc.contributor.author | Choi, Eunhee | - |
dc.contributor.author | Kim, Dong Joon | - |
dc.date.accessioned | 2021-09-01T19:41:14Z | - |
dc.date.available | 2021-09-01T19:41:14Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0192-0790 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67746 | - |
dc.description.abstract | Goals: We aimed to investigate significant factors influencing the long-term prognosis of patients who survived acute-on-chronic liver failure (ACLF). Background: The mortality of ACLF is predominantly affected by the organ failure severity. However, long-term outcomes of patients who survive ACLF are not known. Study: A cohort of 1084 cirrhotic patients who survived for more than 3 months following acute deterioration of liver function was prospectively followed. ACLF was defined by the European Association for the Study of the Liver Chronic Liver Failure Consortium definition. Results: The mean follow-up duration was 19.4 +/- 9.9 months. In the subgroup of patients without previous acute decompensation (AD), ACLF occurrence did not affect long-term outcomes. However, in patients with previous AD, ACLF negatively affected long-term transplant-free survival even after overcoming ACLF (hazard ratio, 2.00, P=0.012). Previous AD was the significant predictive factor of long-term mortality and was independent of the Model for End-stage Liver Disease score in these ACLF-surviving patients. Organ failure severity did not affect transplant-free survival in patients who survived an ACLF episode. Conclusions: A prior history of AD is the most important factor affecting long-term outcomes following an ACLF episode regardless of Model for End-stage Liver Disease score. Prevention of a first AD episode may improve the long-term transplant-free survival of liver cirrhosis patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | CIRRHOTIC-PATIENTS | - |
dc.subject | MORTALITY | - |
dc.subject | DECOMPENSATION | - |
dc.subject | SCORE | - |
dc.title | Long-term Prognosis of Acute-on-Chronic Liver Failure Survivors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Young Kul | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Joon | - |
dc.identifier.doi | 10.1097/MCG.0000000000000987 | - |
dc.identifier.scopusid | 2-s2.0-85041627344 | - |
dc.identifier.wosid | 000458415900014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL GASTROENTEROLOGY, v.53, no.2, pp.134 - 141 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL GASTROENTEROLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL GASTROENTEROLOGY | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 134 | - |
dc.citation.endPage | 141 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | CIRRHOTIC-PATIENTS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | DECOMPENSATION | - |
dc.subject.keywordPlus | SCORE | - |
dc.subject.keywordAuthor | acute-on-chronic liver failure | - |
dc.subject.keywordAuthor | decompensation | - |
dc.subject.keywordAuthor | organ failure | - |
dc.subject.keywordAuthor | survival | - |
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