Apoptotic changes in a full-lengthened immobilization model of rat soleus muscle
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, Hye Rim | - |
dc.contributor.author | Park, Eui Ho | - |
dc.contributor.author | Moon, Sun Wook | - |
dc.contributor.author | Kim, Ji Won | - |
dc.contributor.author | Cho, Hwi Young | - |
dc.contributor.author | Han, Hee Chul | - |
dc.date.accessioned | 2021-09-01T19:53:02Z | - |
dc.date.available | 2021-09-01T19:53:02Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0148-639X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67791 | - |
dc.description.abstract | Introduction: Lengthened immobilization may prevent muscle shortening, and help maintain normal muscle length. However, its apoptotic effects remain unclear. We evaluated the effects of long-term immobilization on apoptotic proteins. Methods: Rat soleus muscles were immobilized by casting in a neutral (NEUT) or lengthened (LENG) position for 21 days. We evaluated dynamic weight load and muscle atrophy following the 21-day period using hematoxylin and eosin staining. We measured Bax (pro-apoptotic Bcl-2 family member), MyoD (myogenic differentiation factor D), MYH (myosin heavy chain), and cleaved poly(ADP-ribose)polymerase levels and examined apoptotic nucleus expression. Results: Decreased dynamic weight load and muscle atrophy changes were observed in LENG. Both NEUT and LENG showed significantly reduced levels of MYH. LENG showed a significant increase in Bax and MyoD expression as well as in the number of apoptotic nuclei. Conclusions: Long-term lengthened immobilization may increase apoptotic changes and decrease muscle formation proteins in muscle. Muscle Nerve 59:263-269, 2019 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | ATROPHY | - |
dc.subject | DISUSE | - |
dc.subject | GENES | - |
dc.subject | DEATH | - |
dc.subject | MYOD | - |
dc.title | Apoptotic changes in a full-lengthened immobilization model of rat soleus muscle | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hye Rim | - |
dc.contributor.affiliatedAuthor | Park, Eui Ho | - |
dc.contributor.affiliatedAuthor | Moon, Sun Wook | - |
dc.contributor.affiliatedAuthor | Han, Hee Chul | - |
dc.identifier.doi | 10.1002/mus.26359 | - |
dc.identifier.scopusid | 2-s2.0-85058777077 | - |
dc.identifier.wosid | 000456164900027 | - |
dc.identifier.bibliographicCitation | MUSCLE & NERVE, v.59, no.2, pp.263 - 269 | - |
dc.relation.isPartOf | MUSCLE & NERVE | - |
dc.citation.title | MUSCLE & NERVE | - |
dc.citation.volume | 59 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 263 | - |
dc.citation.endPage | 269 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | DISUSE | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | MYOD | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | Bax | - |
dc.subject.keywordAuthor | casting | - |
dc.subject.keywordAuthor | lengthened immobilization | - |
dc.subject.keywordAuthor | lengthening | - |
dc.subject.keywordAuthor | soleus | - |
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